Malignant melanoma and pregnancy.
Malignant melanoma and pregnancy.
复制标题
恶性黑色素瘤和怀孕。
DOI：
10.1097/00000637-199201000-00024
复制
发表时间：
1992
影响因子：
1.5
通讯作者：
Seigler,HF
中科院分区：
文献类型：
--
作者：
SlingluffJr,CL;Seigler,HF
在100例妊娠期诊断为黑色素瘤的患者中，平均随访6.8年，与非妊娠女性人群相比，妊娠组的无病间隔明显缩短。中位无病间隔分别为5.8年和11.9年。妊娠患者发生淋巴结转移的时间较短（p= 0.015）。10年时，48%的妊娠患者发生淋巴结转移，而非妊娠患者仅为26%。多变量分析表明，当控制肿瘤部位、厚度和Clark水平时，诊断时妊娠与转移性疾病的发展显著相关（p= 0.008）。然而，妊娠不是患者死亡的危险因素。关于怀孕在黑色素瘤中的作用，文献仍然存在分歧;然而，最近的系列显示生存率没有差异。多项研究未能显示女性激素对黑色素瘤细胞或黑色素瘤的发病率或进展的显着影响。
Among 100 patients diagnosed with melanoma during pregnancy and followed a mean of 6.8 years, when compared with a nonpregnant female population, there was a significantly shorter disease-free interval for the pregnant group. Median disease-free intervals were 5.8 and 11.9 years, respectively. The time to development of lymph node metastases was shorter in the pregnant patients (p= 0.015). Nodal metastases developed in 48% of the pregnant patients and only 26% of the nonpregnant patients, at 10 years. Multivariate analysis demonstrated that pregnancy at diagnosis was significantly associated with the development of metastatic disease (p= 0.008), when controlling for tumor site, thickness, and Clark level. Pregnancy, however, was not a risk factor for patient mortality. The literature continues to be split on the role of pregnancy in melanoma; however, most recent series show no difference in survival. Multiple studies have failed to show significant effects of female hormones on melanoma cells or on the incidence or progression of melanoma.