The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase.
The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase.
复制标题
维生素C和超氧化物导致DNA链断裂的机制以及过氧化氢酶和超氧化物歧化酶的保护作用。
DOI：
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发表时间：
1976
影响因子：
14.9
通讯作者：
T. M. Elgert
中科院分区：
文献类型：
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作者：
A. R. Morgan;R. Cone;T. M. Elgert
Vitamin C breaks DNA only in the presence of oxygen. Superoxide dismutase has no effect on the reaction but catalase suppresses it. Superoxide also gives rise to breaks in DNA suppressible by both superoxide dismutase and catalase. The hydroxyl radical seems to be the agent responsible for strand cleavage itself.
