Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin.
Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin.
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DOI：
10.1186/s12943-017-0631-x
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发表时间：
2017-03-21
期刊：
影响因子：
37.3
通讯作者：
Oliver FJ
中科院分区：
文献类型：
--
作者：
Delgado-Bellido D;Serrano-Saenz S;Fernández-Cortés M;Oliver FJ
血管生成拟态（vasculogenicmimicry，VM）是不同来源的肿瘤细胞中存在的一种不依赖于内皮血管的血液供应系统。它反映了表达血管细胞标志物和肿瘤血管线的侵袭性肿瘤细胞的可塑性。VM的存在与高肿瘤分级、短生存期、侵袭和转移相关。内皮细胞（EC）表达钙粘蛋白超家族的各种成员，特别是血管内皮（VE-）钙粘蛋白，它是内皮粘附连接的主要粘附受体。在与VM相关的某些癌症类型中观察到VE-钙粘蛋白的异常血管外表达。在这篇综述中，我们专注于非内皮VE-钙粘蛋白作为一个突出的因素参与收购的管状结构的侵略性肿瘤细胞，我们总结了具体的信号通路，与转分化和干细胞样表型和治疗的机会，来自深入了解的特殊性的生物学VE-钙粘蛋白和其他关键组件的VM。
Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in tumor cells from different origins. It reflects the plasticity of aggressive tumor cells that express vascular cell markers and line tumor vasculature. The presence of VM is associated with a high tumor grade, short survival, invasion and metastasis. Endothelial cells (ECs) express various members of the cadherin superfamily, in particular vascular endothelial (VE-) cadherin, which is the main adhesion receptor of endothelial adherent junctions. Aberrant extra-vascular expression of VE-cadherin has been observed in certain cancer types associated with VM. In this review we focus on non-endothelial VE-cadherin as a prominent factor involved in the acquisition of tubules-like structures by aggressive tumor cells and we summarize the specific signaling pathways, the association with trans-differentiation and stem-like phenotype and the therapeutic opportunities derived from the in-depth knowledge of the peculiarities of the biology of VE-cadherin and other key components of VM.