Sexually transmitted infections in pregnant adolescents: prevalence and association with maternal and foetal morbidity
Sexually transmitted infections in pregnant adolescents: prevalence and association with maternal and foetal morbidity
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DOI：
10.1111/j.1468-3083.2011.04194.x
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发表时间：
2012-08-01
影响因子：
9.2
通讯作者：
Pereira, F.
中科院分区：
文献类型：
--
作者：
Borges-Costa, J.;Matos, C.;Pereira, F.
背景怀孕的青少年是性传播感染的高发人群，也是不良生育结局的高危人群。目的了解青春期妊娠期性传播感染的流行情况及其与不良出生结局的关系。方法类似于前瞻性研究，对怀孕的青少年进行面对面访谈，然后采集首次尿液和宫颈拭子，进行沙眼衣原体和淋球菌的聚合酶链式反应检测。分娩后，还审查了其他感染的血清学和微生物学结果以及有关母婴发病率的数据的临床档案。采用了5%的显著性水平。结果204名孕期青少年符合纳入标准，沙眼衣原体感染率为11.8%，淋球菌感染率为4.9%，多数为无症状。没有发现梅毒或人类免疫缺陷病毒抗体。孕产妇发病率3.4%，早产儿11.8%，低出生体重儿9.8%。在统计上观察到产妇发病率与淋病、青少年和严重早产儿之间以及沙眼衣原体和/或淋病感染与低出生体重之间存在显著的相关性。结论性传播感染常无症状，可引起母婴发病。因此，不应错过怀孕提供的筛查和咨询机会，特别是在青少年中。
Background Pregnant adolescents have a high incidence of sexually transmitted infections and higher risk of adverse birth outcome. Objectives To assess the prevalence of sexually transmitted infections in pregnant adolescents and the associations between these infections and adverse birth outcome. Methods similar to A prospective study with a face-to-face interview to pregnant adolescents was followed by first-void urine and cervical swabs collection for polymerase chain reaction testing for Chlamydia trachomatis and Neisseria gonorrhoeae. After child delivery, clinical files were also reviewed for serological and microbiological results for other infections and data concerning maternalfoetal morbidity. A 5% level of significance was used. Results The inclusion criteria were fulfilled by 204 pregnant adolescents, and the prevalence of C. trachomatis was 11.8% and of N. gonorrhoeae was 4.9%, with the majority being asymptomatic. No antibodies for syphilis or human immunodeficiency virus were found. Maternal morbidity occurred in 3.4%, prematurity was observed in 11.8% of the newborns and low birth weight in 9.8%. Statistically significant associations were observed between maternal morbidity and the presence of gonorrhoea, younger adolescents and severe prematurity and between infection with C. trachomatis and/or N. gonorrhoea and low birth weight. Conclusions Sexually transmitted infections are frequently asymptomatic and cause maternalfoetal morbidity. The opportunity that pregnancy offers for screening and counselling should not therefore be missed, especially in adolescents.