REGIONAL BRAIN DOPAMINE METABOLISM - A MARKER FOR THE SPEED, DIRECTION, AND POSTURE OF MOVING ANIMALS
REGIONAL BRAIN DOPAMINE METABOLISM - A MARKER FOR THE SPEED, DIRECTION, AND POSTURE OF MOVING ANIMALS
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DOI：
10.1126/science.4012312
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
YAMAMOTO, BK
中科院分区：
文献类型：
--
作者：
FREED, CR;YAMAMOTO, BK
大脑中的多巴胺是正常运动所必需的。为了确定运动强度和大脑多巴胺代谢变化之间是否存在精确的关系，大鼠在直跑步机和圆形跑步机上以不同的速度和不同的身体姿势进行跑步。多巴胺及其代谢产物3，4-二羟基苯乙酸在尾状核和伏隔核内的浓度增加，与动物的速度和角度姿势有直接关系。伏隔核多巴胺代谢受运动速度和方向的影响较大，而尾状核多巴胺和3，4-二羟基苯乙酸受体位和方向影响最大。
Brain dopamine is necessary for normal movement. To determine whether there is a precise relation between the intensity of movement and changes in brain dopamine metabolism, rats were run on straight and circular treadmills at different speeds and with different body postures. Concentrations of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid increased in the caudate and accumbens nuclei in direct relation to the speed and angular posture of the animals. Dopamine metabolism in the nucleus accumbens was more strongly linked to the speed and direction of movement, while in the caudate nucleus dopamine and 3,4-dihydroxyphenylacetic acid were affected most by posture and direction.