Evaluation of visual acuity and color vision in normal human eyes with a sutureless temporary amniotic membrane patch.
Evaluation of visual acuity and color vision in normal human eyes with a sutureless temporary amniotic membrane patch.
复制标题
使用无缝线临时羊膜补片评估正常人眼的视力和色觉。
DOI：
10.1016/j.ajo.2007.08.003
复制
发表时间：
2007
影响因子：
4.2
通讯作者：
Tseng,SchefferCG
中科院分区：
文献类型：
--
作者：
Ijiri,Shigeyuki;Kobayashi,Akira;Sugiyama,Kazuhisa;Tseng,SchefferCG
目的：评价免缝合羊膜补片对正常人眼视觉功能的影响。方法：将PROKERA生产的免缝合羊膜补片植入6例正常人的1只眼。4名患者插入了4个套件（各1个），2名患者插入了6个套件（各3个）。比较植入前后未矫正的远视力和近视力、色觉、通过角膜厚度测量法测量的羊膜厚度和总症状评分。在植入后30分钟内，平均远视力从-0.22 ± 0.06降至0.92 ± 0.45对数最小分辨角（logMAR）。在插入的10套PROKERA中，5套近视力表的最大视标（1.0 logMAR）无法识别，但所有受试者仍保留了由面板D-15评价的色觉。总症状评分增加至47.8 ± 9.1分（最高100分）。症状中异物感（17.8 ± 3.6）和视物模糊（17.8 ± 4.4）的总分较高。远视力丧失和症状评分增加与羊膜厚度（平均为67.6 ± 25.2 μm）无关。然而，羊膜是不透明的倾向于提供相对较好的visual acuities. CONCLUSION由于在PROKERA的缝合羊膜补丁的相对非透明性，远，近视力下降，在正常人的眼睛。插入后观察到的异物感主要来自刚性支撑裙缘。
PURPOSETo evaluate how sutureless amniotic membrane patches may affect visual functions in normal human eyes.DESIGNProspective intervention study.METHODSTen sets of sutureless amniotic membrane patch manufactured as PROKERA were inserted in one eye of six normal patients. Four sets (one each) were inserted in four patients, while six sets (three each) were inserted in two patients. Uncorrected distant and near visual acuities, color vision, amniotic membrane thickness measured by pachymetry, and total symptom scores were compared before and after insertion.RESULTSWithin 30 minutes after insertion, mean distant visual acuities decreased from −0.22 ± 0.06 to 0.92 ± 0.45 logarithmic minimum angle of resolution (logMAR). Among 10 sets of PROKERA inserted, the largest optotype (1.0 logMAR) of the near vision chart could not be recognized in five, but color vision evaluated by Panel D-15 was still preserved in all. Total symptom scores increased to 47.8 ± 9.1 points (maximum, 100 points). Among symptoms, total scores for foreign body sensation (17.8 ± 3.6) and blurred vision (17.8 ± 4.4) were high. Loss of distant visual acuity and increases of symptom scores were not correlated with amniotic membrane thickness, of which the mean was 67.6 ± 25.2 μm. However, amniotic membrane that was less opaque tended to provide relatively good visual acuities.CONCLUSIONBecause of the relative non-transparency of sutureless amniotic membrane patches in PROKERA, distant and near visual acuities decreased in normal human eyes. The foreign body sensation noted after insertion is primarily derived from the rigid supporting skirt.