T-cell alpha beta(+) and gamma delta(+) deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium
T-cell alpha beta(+) and gamma delta(+) deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium
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DOI：
10.1073/pnas.93.21.11774
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发表时间：
1996-10-15
影响因子：
11.1
通讯作者：
Hayday, AC
中科院分区：
文献类型：
--
作者：
Roberts, SJ;Smith, AL;Hayday, AC
脊椎动物免疫系统含有携带α β或γ δ T细胞抗原受体（TCR）的T细胞。α β T细胞执行所有充分表征的T细胞效应器功能，而γ δ（+）细胞的生物学功能仍不清楚。特别令人感兴趣的是γ δ细胞在上皮感染期间的作用，因为γ δ（+）细胞通常在上皮内丰富。艾美耳球虫属是细胞内的原生动物，感染大多数脊椎动物的上皮细胞，引起球虫病。这项研究表明，在对蠕虫状艾美耳球虫的反应中，缺乏α β T细胞的小鼠显示出保护性免疫缺陷，而缺乏γ δ（+）细胞的小鼠显示出夸大的肠道损伤，这显然是由于未能调节α β T细胞反应的后果。在感染和自身免疫性疾病期间的免疫下调作用可能是γ δ（+）细胞的一般作用。
Vertebrate immune systems contain T cells bearing either alpha beta or gamma delta T-cell antigen receptors (TCRs). alpha beta T cells perform all well-characterized T-cell effector functions, while the biological functions of gamma delta(+) cells remain unclear. Of particular interest is the role of gamma delta cells during epithelial infections, since gamma delta(+) cells are commonly abundant within epithelia. Eimeria spp. are intracellular protozoa that infect epithelia of most vertebrates, causing coccidiosis. This study shows that in response to Eimeria vermiformis, mice lacking alpha beta T cells display defects in protective immunity, while mice lacking gamma delta(+) cells display exaggerated intestinal damage, apparently due to a failure to regulate the consequences of the alpha beta T cell response. An immuno-downregulatory role during infection, and during autoimmune disease, may be a general one for gamma delta(+) cells.