Differentiation of EBV‐induced post‐transplant Hodgkin lymphoma from Hodgkin‐like post‐transplant lymphoproliferative disease
Differentiation of EBV‐induced post‐transplant Hodgkin lymphoma from Hodgkin‐like post‐transplant lymphoproliferative disease
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EB 病毒诱导的移植后霍奇金淋巴瘤与霍奇金样移植后淋巴增殖性疾病的鉴别
DOI：
10.1111/j.1399-3046.2007.00816.x
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发表时间：
2008
影响因子：
1.3
通讯作者：
C. Niemeyer
中科院分区：
文献类型：
--
作者：
J. Rohr;H. Wagner;M. Lauten;H. Wacker;E. Jüttner;C. Hanke;M. Pohl;C. Niemeyer
摘要： SOT 后发生淋巴瘤是预防移植排斥所需的免疫抑制治疗的众所周知的并发症。 EB 病毒由于具有转化受感染细胞的能力，因此在淋巴瘤的发病机制中发挥着核心作用。区分 PTLD 和恶性淋巴瘤，尤其是 HL 可能具有挑战性。我们报告了两名患者，他们在 SOT 几年后出现了 EBV 相关淋巴瘤。淋巴结的组织学检查导致两名患者诊断为 HL，并根据当前的治疗方案开始接受化疗。一名患者的快速完全缓解促使我们分析 EBV 潜伏基因的表达模式。在该患者中，EBV 表达谱显示为 III 型潜伏期，提示诊断为霍奇金样 PTLD。另一名患者需要六个疗程的化疗加放疗才能达到完全缓解。在他的肿瘤细胞中，发现了限制性 EBV 潜伏期 II 型模式，提示诊断为经典 HL。这两个病例表明，在具有 HL 组织学特征的移植后淋巴瘤中，分析 EBV 蛋白的表达模式可能有助于区分 PTLD 和 HL。
Abstract: The development of lymphomas after SOT is a well‐known complication of the immunosuppressive therapy necessary to prevent graft rejection. Epstein‐Barr virus plays a central role in the pathogenesis of lymphomas because of its ability to transform infected cells. Differentiating PTLD from malignant lymphomas, especially HL can be challenging. We report on two patients, who developed EBV‐associated lymphomas several years after SOT. A histological examination of lymph nodes led to a diagnosis of HL in both patients, who were started on chemotherapy according to current treatment protocols. A rapid and complete remission in one patient prompted us to analyze the expression pattern of EBV‐latency genes. In this patient, the EBV expression profile revealed a latency type III suggesting the diagnosis of Hodgkin‐like PTLD. The other patient required six courses of chemotherapy plus radiotherapy to reach a complete remission. In his tumor cells, a restricted EBV‐latency type II pattern was found, suggesting a diagnosis of classical HL. These two cases demonstrate that in post‐transplant lymphomas with histological features of HL, an analysis of the expression pattern of EBV proteins might aid in the differentiation between PTLD and HL.
DOI：
10.1073/pnas.95.20.11963
发表时间：
1998-09-29
影响因子：
11.1
作者：
Kulwichit, W;Edwards, RH;Raab-Traub, N
通讯作者：
Raab-Traub, N