Polyneuropathy with anti-sulfatide and anti-MAG antibodies: Clinical, neurophysiological, pathological features and response to treatment
Polyneuropathy with anti-sulfatide and anti-MAG antibodies: Clinical, neurophysiological, pathological features and response to treatment
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DOI：
10.1016/j.jneuroim.2015.02.009
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发表时间：
2015-04-15
影响因子：
3.3
通讯作者：
Briani, Chiara
中科院分区：
文献类型：
--
作者：
Campagnolo, Marta;Ferrari, Sergio;Briani, Chiara
IgM副蛋白通常对髓鞘相关糖蛋白（MAG）和硫脂具有反应性。我们描述了21例IgM副蛋白血症性神经病变患者的临床和神经生理学发现，以及治疗反应（15例有抗mag抗体，1例有抗硫脂抗体，5例有两种反应性），2例抗硫脂阳性且无血液病。所有患者均有感觉症状，多数有脱髓鞘神经病变。人正常腓肠神经的间接免疫荧光显示不同的染色模式。13例患者中有8例（抗mag抗体6例，抗硫脂抗体1例，抗硫脂抗体和抗mag抗体均有1例）经利妥昔单抗治疗后病情好转。IVIg、类固醇和血浆置换治疗也有不同的疗效。(C) 2015 Elsevier B.V.版权所有
IgM paraproteins often present reactivity to myelin-associated glycoprotein (MAG) and sulfatide.We describe the clinical and neurophysiological findings, and therapy response in 21 patients with IgM paraproteinemic neuropathy (15 with anti-MAG antibodies, 1 with anti-sulfatide antibodies, and 5 with both reactivity), and in 2 with anti-sulfatide positivity and no hematological disease.All patients complained of sensory symptoms, the majority had demyelinating neuropathy. Indirect immunofluorescence on human normal sural nerves disclosed different staining patterns.Eight of 13 patients (6 anti-MAG, 1 anti-sulfatide, 1 both anti-sulfatide and anti-MAG antibodies) improved after Rituximab. IVIg, steroids and plasma-exchange were also administered with different responses. (C) 2015 Elsevier B.V. All rights reserved.