Cancer Therapy-Induced Cardiovascular Toxicity Treatment with apolipoprotein A1 protects mice against doxorubicin-induced cardiotoxicity in a scavenger receptor class B, type I-dependent manner
Cancer Therapy-Induced Cardiovascular Toxicity Treatment with apolipoprotein A1 protects mice against doxorubicin-induced cardiotoxicity in a scavenger receptor class B, type I-dependent manner
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一种清道夫受体类型的药物，用于治疗多种癌症，通过触发心肌细胞凋亡而具有心脏毒性。我们先前表明，在体外用人高密度脂蛋白或其主要结构蛋白人载脂蛋白A1的转基因过表达处理培养的心肌细胞，以依赖于I型清道夫受体B类的方式保护多柔比星诱导的心肌细胞凋亡[达勒姆KK，Chathely KM，Mak KC，Momen A，托马斯CT，Zhao YY，MacDonald ME，Curtis JM，Husain M，Trigatti BL. HDL以清道夫受体B类1型、磷脂酰肌醇3激酶和Akt依赖性方式保护阿霉素诱导的心脏毒性。Am J Physiol Heart Software，拉霍亚，CA）。对于成对比较，使用Shapiro-Wilk或D'Agostino-Pearson综合检验评估正态性，并通过F检验评估等方差。通过的数据通过Student t检验（双尾，不配对）进行分析，而未通过正态性检验的数据通过Mann-Whitney秩和检验进行分析。单因素方差分析用于包含多个组的数据，双因素方差分析用于具有两个或更多个自变量的数据。使用Tukey检验（样本量相等的组）或Tukey-Kramer检验（样本量不等的组）进行事后分析。P（cid：6）0.05时差异具有统计学显著性。
a scavenger receptor type an agent used to treat a variety of cancers, is cardiotoxic by triggering cardiomyocyte apoptosis. We previously showed that treating cultured cardiomyocytes with human high-density lipoprotein in vitro or transgenic overexpression of human apolipoprotein A1, its main structural protein, protects against doxo-rubicin-induced cardiomyocyte apoptosis in a manner dependent on the scavenger receptor class B type I [Durham KK, Chathely KM, Mak KC, Momen A, Thomas CT, Zhao YY, MacDonald ME, Curtis JM, Husain M, Trigatti BL. HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, phosphatidylinositol 3-kinase-, and Akt-dependent manner. Am J Physiol Heart Software, La Jolla, CA). For pairwise comparisons, normality was assessed using the Shapiro-Wilk or D’Agostino-Pearson omnibus test and equal variance by F -test. Data that passed were analyzed by Student’s t -test (2-tailed, unpaired), while data that did not pass the normality test were analyzed by the Mann-Whitney rank-sum test. One-way ANOVA was used for data comprising multiple groups, and two-way ANOVA was used for data with two or more independent variables. Post hoc analysis was performed using the Tukey test for groups of equal sample size or the Tukey-Kramer test for groups with unequal sample size. Differences are considered statistically significant at P (cid:6) 0.05.