How Salmonella became a pathogen
How Salmonella became a pathogen
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DOI：
10.1016/s0966-842x(97)01099-8
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发表时间：
1997-09-01
影响因子：
15.9
通讯作者：
Ochman, H
中科院分区：
文献类型：
--
作者：
Groisman, EA;Ochman, H
在许多病原体中，毒力可以由基因组的单个区域授予。相比之下，沙门氏菌的兼性细胞内生活方式需要大量分布在染色体周围的基因。沙门氏菌的进化标志着几个“致病岛”的获得，每个岛都对这种微生物独特的毒力特性做出了贡献。
In many pathogens, virulence can be conferred by a single region of the genome. In contrast, the facultative intracellular lifestyle of Salmonella demands a large number of genes distributed around the chromosome. The evolution of Salmonella has been marked by the acquisition of several 'pathogenicity islands', each contributing to the unique virulence properties of this microorganism.