MR imaging-histopathologic correlation of radiofrequency thermal ablation lesion in a rabbit liver model: observation during acute and chronic stages.
MR imaging-histopathologic correlation of radiofrequency thermal ablation lesion in a rabbit liver model: observation during acute and chronic stages.
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DOI：
10.3348/kjr.2001.2.3.151
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发表时间：
2001-07
影响因子：
4.8
通讯作者：
Mun WS
中科院分区：
文献类型：
--
作者：
Lee JD;Lee JM;Kim SW;Kim CS;Mun WS
确定MR成像检测射频（RF）热损伤中发生的病理变化的能力，并评估其显示组织坏死程度的准确性。使用射频电极，在18只家兔的肝脏中产生热损伤。该程序包括三个阶段。在急性期，6只动物在用射频能量进行热消融后第二天被处死，2只在第3天被处死。在亚急性期和慢性期，8只家兔接受经皮肝射频消融。在进行MR成像后，分别在术后1、2、4和7周处死两只动物，并进行MR病理对照。在急性期，热消融损伤在大体检查时表现为边界清楚的坏死区域，代表在显微镜检查时观察到的凝固性坏死的早期变化。T2加权像呈低信号，T1加权像呈高信号。钆增强MRI显示中央凝固性坏死周围有一薄的充血边缘。在亚急性期，显微镜检查发现消融病变还显示出广泛的凝固性坏死和明显的炎症。两周后，病变显示坏死区域逐渐吸收，周围有纤维血管边缘。MRI测量的病灶大小与大体病理检查结果相关。磁共振成像可有效显示热消融后发生的组织病理学变化，并准确确定靶区的范围。
To determine the ability of MR imaging to detect the pathological changes occurring in radiofrequency (RF) thermal lesions and to assess its accuracy in revealing the extent of tissue necrosis. Using an RF electrode, thermal lesions were created in the livers of 18 rabbits. The procedure involved three phases. In the acute phase, six animals were killed the day after performing thermal ablation with RF energy, and two on day 3. In the subacute and chronic phases, eight rabbits underwent percutaneous hepatic RF ablation. After performing MR imaging, two animals were sacrificed at 1, 2, 4, and 7 weeks after the procedure, and MR-pathologic correlation was performed. In the acute phase, the thermal ablation lesions appeared at gross examination as well-circumscribed, necrotic areas, representing early change in the coagulative necrosis seen at microscopic examination. They were hypointense on T2-weighted images, and hyperintense on T1-weighted images. Gadolinium-enhanced MR imaging showed that a thin hyperemic rim surrounded the central coagulative necrosis. In the subacute phase, ablated lesions also showed extensive coagulative necrosis and marked inflammation at microscopic examination. Beyond two weeks, the lesions showed gradual resorption of the necrotic area, with a peripheral fibrovascular rim. The size of lesions measured by MR imaging correlated well with the findings at gross pathologic examination. MR imaging effectively demonstrates the histopathological tissue change occurring after thermal ablation, and accurately determines the extent of the target area.