Noradrenaline clearance in hypertensive patients with various degrees of renal function.
Noradrenaline clearance in hypertensive patients with various degrees of renal function.
复制标题
不同程度肾功能的高血压患者去甲肾上腺素清除率。
DOI：
10.1042/cs057213s
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发表时间：
1979
期刊：
影响因子：
6
通讯作者：
M. Kuchii
中科院分区：
文献类型：
--
作者：
Y. Masuyama;T. Nishimura;I. Nishio;M. Kuchii
1.肾功能正常的高血压患者血、尿去甲肾上腺素浓度显著高于正常对照组，肾功能轻、中度损害的高血压患者血、尿去甲肾上腺素浓度与正常对照组相同。2.高血压合并严重肾功能损害患者血浆去甲肾上腺素浓度显著高于对照组，尿去甲肾上腺素排泄量显著低于对照组。3.在严重肾功能不全的受试者中，通过游离血浆去甲肾上腺素和总尿去甲肾上腺素计算的去甲肾上腺素清除率显著降低。4.高血压病肾功能严重损害者血浆结合去甲肾上腺素升高，无肾功能损害者尿结合去甲肾上腺素升高。
1. Hypertensive patients with normal renal function showed significantly higher plasma urinary noradrenaline than the normotensive controls, and the hypertensive patients with mild to moderate disturbance of renal function showed the same noradrenaline concentration as the controls. 2. Hypertensive patients with severe renal function disturbance showed significantly higher plasma noradrenaline concentrations and lower urinary noradrenaline excretion than the controls. 3. Noradrenaline clearance calculated by free plasma noradrenaline and total urinary noradrenaline was significantly decreased in those subjects with severe renal dysfunction. 4. Conjugated plasma noradrenaline was increased in the hypertensive patients with the severe disturbance of renal function, and conjugated urinary noradrenaline increased in those without severe renal dysfunction.