Human Sertoli cells produce inhibin in vitro: an additional marker to assess the seminiferous epithelium development.
Human Sertoli cells produce inhibin in vitro: an additional marker to assess the seminiferous epithelium development.
复制标题
人支持细胞在体外产生抑制素：评估生精上皮发育的附加标记。
DOI：
10.1093/oxfordjournals.humrep.a136213
复制
发表时间：
1995
影响因子：
6.1
通讯作者：
S. Carreau
中科院分区：
文献类型：
--
作者：
S. Carreau
Martin-du-Pan和Bischof（1995）的论文提出了评估正常和不育男性生精活性的整个问题。卵泡刺激素（FSH）浓度的解释和睾丸活检的价值进行了讨论。在这场辩论中，我们希望再次审视人类支持细胞的功能，并探索可能用作细胞功能紊乱的标志物的新参数。支持细胞的结构以及它们与邻近生殖细胞之间复杂的连接有助于（与激素供应一起）提供生殖细胞完全发育所需的所有营养，从而维持精子发生。在人类睾丸中，支持细胞的基本组织结构与大鼠中描述的相似，并且不仅支持细胞之间，而且支持细胞与生殖细胞之间以及支持细胞与细胞外基质之间均已证实存在特异性连接复合物（综述见Russell，1993; Schulze和Holstein，1993）。
The paper by Martin-du-Pan and Bischof (1995) raises the whole question of assessment of spermatogenic activity in normal and infertile men. The interpretation of follicle stimulating hormone (FSH) concentrations and the value of testicular biopsies are discussed. In this debate, we wish to take a second look at Sertoli cell function in the human, and explore new parameters which might be used as markers of disturbed cell function.Within the seminiferous tubule of the mammalian testis, the structure of the Sertoli cells and the sophisticated junctions between them and the neighbouring germ cells contribute (together with hormonal supplies) to bring all the nutrients required for complete development of germ cells and, consequently, to maintaining spermatogenesis. In the human testis, the basic organization of the Sertoli cells is similar to that described in the rat and specific junctional complexes have been demonstrated between not only Sertoli cells but also between Sertoli and germ cells, and between Sertoli cells and the extracellular matrix (for reviews see Russell, 1993; Schulze and Holstein, 1993).