FoxM1: a master regulator of tumor metastasis.
FoxM1: a master regulator of tumor metastasis.
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DOI：
10.1158/0008-5472.can-11-0640
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发表时间：
2011-07-01
期刊：
影响因子：
11.2
通讯作者：
Park HJ
中科院分区：
文献类型：
--
作者：
Raychaudhuri P;Park HJ
FOXM1转录因子基因在癌症中过度表达。它的表达受到致癌信号通路和活性氧的刺激。它也是肿瘤抑制基因调控的靶点。FOXM1的转录活性依赖于Cyclin/CDKs和Plk1的激活。FOXM1刺激与细胞周期进程有关的几个基因的表达。此外，它还通过刺激抗氧化剂基因的表达和减少氧化应激来支持肿瘤细胞的增殖。一项新的研究提供了证据，在缺乏其抑制物肿瘤抑制因子Arf的情况下，FOXM1促进了肝细胞癌(HCC)的转移。它在肝癌细胞中诱导了EMT样表型，增加了细胞的迁移，并在转移的远端器官诱导了转移前的生态位。FOXM1直接激活参与多步转移的基因。在这篇综述中，我们讨论了FOXM1在肿瘤转移中发挥主要调节作用的证据。
The FoxM1 transcription factor gene is over-expressed in cancer. Its expression is stimulated by oncogenic signaling pathways and reactive oxygen species. It is also a target of regulation by the tumor suppressor genes. The transcriptional activity of FoxM1 depends upon activation by the Cyclin/Cdks as well as Plk1. FoxM1 stimulates expression of several genes involved in the cell cycle progression. Moreover, it supports proliferation of tumor cells by stimulating expression of the antioxidant genes and reducing oxidative stress. A new study provided evidence that FoxM1, in the absence of its inhibitor, the tumor suppressor Arf, drives metastasis of hepatocellular carcinoma (HCC). It induces an EMT-like phenotype in HCC cells, increases cell-migration and induces pre-metastatic niche at the distal organ of metastasis. FoxM1 directly activates genes involved in multiple steps of metastasis. In this review, we discuss the evidence for a master regulatory role of FoxM1 in tumor metastasis.