Gemcitabine: Actions and interactions
Gemcitabine: Actions and interactions
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DOI：
10.1080/07328319708006168
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Gandhi, V
中科院分区：
文献类型：
--
作者：
Plunkett, W;Huang, P;Gandhi, V
吉西他滨是一种通过多种机制起作用的核苷类似物。三磷酸的掺入和随后的DNA复制和修复的抑制似乎是主要的作用模式。核糖核苷酸还原酶受吉西他滨二磷酸盐抑制，这是一种导致代谢自增强效应的活性。
Gemcitabine is a nucleoside analog that acts by multiple mechanisms. Incorporation of the triphosphate and subsequent inhibition of DNA replication and repair appears to be the major mode of action. Ribonucleotide reductase is inhibited by gemcitabine diphosphate, an activity that leads to metabolic self-potentiating effects.