Increased Mean Platelet Volume in Behcet's Disease with Thrombotic Tendency
Increased Mean Platelet Volume in Behcet's Disease with Thrombotic Tendency
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DOI：
10.1620/tjem.221.119
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发表时间：
2010-06-01
影响因子：
2.2
通讯作者：
Ozdemir, Ramazan
中科院分区：
文献类型：
--
作者：
Acikgoz, Nusret;Karincaoglu, Yelda;Ozdemir, Ramazan
白塞病（BD）和血小板聚集之间的关系尚未得到充分的研究。平均血小板体积（MPV）是血小板功能的标志物，MPV增加已被确定为血管事件复发的独立危险因素。BD的特征是静脉和动脉血栓形成的复发性血管炎。然而，BD血栓形成倾向的确切致病机制尚不清楚。我们假设这些患者的血栓性并发症与MPV之间可能存在相关性。因此，我们使用一种简单的标记物MPV（血小板大小最准确的测量方法）来研究BD患者的血小板活化。共纳入60例BD患者和40例年龄和性别匹配的对照。根据血栓形成的存在（n = 22）或不存在（n = 38）以及临床活动（n = 30）或非活动（n = 30）状态将BD患者分为亚组。BD患者的MPV高于对照组（8.14 +/- 0.8 vs. 7.48 +/- 0.3 fl，p = 0.001）。在BD患者中，有血栓形成的患者的MPV大于无血栓形成的患者（8.45 +/- 1.0 vs. 7.96 +/- 0.7 fl，p = 0.038）。而活动期和非活动期BD患者的MPV无显著差异。MPV的增加与疾病活动无关，并且血栓形成的存在与BD患者的MPV较高相关。因此，抗血小板治疗可能有助于预防BD患者的血栓性并发症。
The relationship between Behcet's disease (BD) and platelet aggregation has not sufficiently been investigated yet. Mean platelet volume (MPV) is a marker of platelet function, and the increase in MPV has been identified as an independent risk factor of recurrent vascular events. BD is characterized by a relapsing vasculitis of the venous as well as arterial thrombosis. However, the precise pathogenic mechanisms underlying thrombotic tendency in BD are not known. We hypothesized that there might be an association between thrombotic complication and MPV in these patients. Therefore, we investigated activation of platelets in patients with BD using a simple marker, MPV, the most accurate measure of platelet size. A total of 60 patients with BD and 40 age- and gender-matched controls were included. The BD patients were divided into subgroups based on the presence (n = 22) or absence of thrombosis (n = 38) and clinically active (n = 30) or inactive (n = 30) state. MPV was higher in patients with BD than controls (8.14 +/- 0.8 vs. 7.48 +/- 0.3 fl, p = 0.001). Among BD patients, MPV was larger in patients with thrombosis than those without thrombosis (8.45 +/- 1.0 vs. 7.96 +/- 0.7 fl, p = 0.038). However, there was no significant difference in MPV between BD patients with active and inactive states. The increase in MPV is independent of the disease activity, and the presence of thrombosis is associated with higher MPV in BD patients. Therefore, antiplatelet therapy may be useful to prevent thrombotic complications in BD patients.