Xerostomic complaints induced by an anti-sialogogue in healthy young vs. older adults.
Xerostomic complaints induced by an anti-sialogogue in healthy young vs. older adults.
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健康年轻人与老年人中抗唾液酸引起的口干症。
DOI：
10.1111/j.1754-4505.2001.tb00251.x
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Ship,JA
中科院分区：
文献类型：
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作者：
Patel,PS;Ghezzi,EM;Ship,JA
口腔干燥和唾液功能减退的投诉在老年人中很常见。然而，最近的研究报告称，与年轻人相比，脱水诱导的唾液功能减退导致老年人口腔干燥症的投诉较少。这可能会使老年人更容易出现口腔问题，而这些问题随后不会得到医疗保健提供者的关注。由于已知许多药物可抑制流涎，本研究试图确定抗胆碱能药物（格隆溴铵）是否对年轻人与老年人的口干症有不同的影响。对18名年轻（年龄20-38岁）和18名老年（年龄60-77岁）健康成人静脉给予4.0 g/kg剂量的格隆溴铵。给药后6小时，收集刺激的腮腺唾液流，并进行8项视觉焦虑量表（VAS）主观口干测试。在静脉注射格隆溴铵后的几个时间点，老年人的唾液流速始终低于年轻人。对于口干症投诉的一些指标（至首次投诉的时间;至最大投诉的时间;平均最大投诉），所有VAS项目均无年龄相关差异。然而，证明了老年人口腔干燥投诉增加的趋势（恢复时间;投诉总持续时间; 6小时时口腔干燥的数量）。这些研究结果表明，给予相同剂量的抗唾液酸剂，健康老年人的唾液功能减退更严重，而口干症的投诉增加并不一致。
Complaints of xerostomia and salivary hypofunction are common in older adults. However, recent studies reported that dehydration‐induced salivary hypofunction caused fewer xerostomic complaints in older compared with young adults. This may predispose older adults to developing oral problems that will subsequently not receive attention from health care providers. Since many medications are known to inhibit salivation, this study attempted to determine if an anticholinergic drug (glycopyrrolate) had a differential effect on xerostomic complaints in young vs. older adults. Eighteen young (age 20–38 yrs) and 18 older (age 60–77 yrs) healthy adults were given a 4.0 g/kg dose of IV glycopyrrolate. For 6 hrs after drug administration, stimulated parotid salivary flow was collected, and an eight‐item Visual Analogue Scale (VAS) subjective xerostomia test was given. At several time points post‐IV glycopyrrolate, salivary flow rates were consistently lower in older compared with young adults. For some measures of xerostomic complaint (time to first complaint; time to maximum complaint; mean maximum complaint), there were no age‐related differences for all VAS items. However, a trend for increased xerostomic complaints in older adults was demonstrated (time to recovery; total duration of complaint; number xerostomic at 6 hrs). These findings suggest that, given equal doses of an anti‐sialogogue, salivary hypofunction is greater in healthy older adults, while increased complaints of xerostomia are not as consistent.