Olfactory bulbectomy enhances sensitization of the acoustic startle reflex produced by acute or repeated stress.
Olfactory bulbectomy enhances sensitization of the acoustic startle reflex produced by acute or repeated stress.
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嗅球切除术增强了急性或重复应激产生的听觉惊吓反射的敏感性。
DOI：
10.1037//0735-7044.111.1.80
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发表时间：
1997
影响因子：
1.9
通讯作者：
Davis,M
中科院分区：
文献类型：
--
作者：
McNish,KA;Davis,M
通过3个实验观察嗅球切除对惊声反射和休克致敏的影响。在实验1中，去球动物的基线惊吓反应在手术后适度增加，恐惧增强惊吓的正常获得，但与假手术对照相比，在条件反射过程中基线惊吓反应明显增加。在实验2和3中，去球的动物表现出休克诱导的惊吓反射对休克强度的敏化，而在假手术和未手术的对照组中没有产生敏化。这些数据表明，嗅球切除术导致对压力源的易感性增加，这可能是由杏仁核或其他参与调节压力和焦虑的结构的去抑制介导的。因此，抑郁症的嗅球切除模型可能与其他应激性抑郁症模型有一些相似之处。
The effects of olfactory bulbectomy on the acoustic startle reflex and shock-induced sensitization of the startle reflex were examined in 3 experiments. In Experiment 1, bulbectomized animals showed a modest increase in baseline startle responding following surgery, and normal acquisition of fear-potentiated startle, but a pronounced increase in baseline startle responding during the course of conditioning relative to sham-operated controls. In Experiments 2 and 3, bulbectomized animals showed shock-induced sensitization of the startle reflex to shock intensities that did not produce sensitization in sham and unoperated controls. These data suggest that olfactory bulbectomy results in an increased vulnerability to stressors, which may be mediated by a disinhibition of the amygdala or other structures involved in mediating stress and anxiety. Thus, the olfactory bulbectomy model of depression may share some similarities with other stress-induced models of depression.