Risk factors of distant metastasis in patients with squamous cell carcinoma of the oral cavity
Risk factors of distant metastasis in patients with squamous cell carcinoma of the oral cavity
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DOI：
10.1016/j.oooo.2015.11.022
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发表时间：
2016-05-01
影响因子：
2.9
通讯作者：
Umeda, Masahiro
中科院分区：
文献类型：
--
作者：
Sakamoto, Yuki;Matsushita, Yuki;Umeda, Masahiro
目标。虽然近年来口腔癌的局部控制率有所提高，但发生远处转移（DM）的患者数量有所增加。本研究旨在探讨口腔癌手术患者发生糖尿病的相关临床病理因素。研究设计。这是一项对252例接受口腔鳞状细胞癌手术的患者的回顾性研究。我们检查了各种临床病理因素，以确定它们与糖尿病发展的关系。21例发生糖尿病。单因素分析显示，神经周围浸润、病理阳性淋巴结（pN+）、颈部转移水平、囊外扩散、局部复发、颈部复发、局部区域控制、术后放疗与DM的发生有关。多因素logistic分析显示，pN+、颈部4级和5级受累、局部复发是DM的独立危险因素。pN+、下颈部转移、局部复发是口腔癌患者发生糖尿病的危险因素。
Objective. Although the locoregional control rate of oral cancer has improved recently, the number of patients developing distant metastasis (DM) has increased. The aim of this study is to investigate the clinicopathologic factors related to DM in patients with oral cancer undergoing surgery.Study Design. This was a retrospective study of 252 patients who underwent surgery for squamous cell carcinoma of the oral cavity. Various clinicopathologic factors were examined to determine their relationship to the development of DM.Results. DM occurred in 21 patients. Univariate analysis showed that perineural invasion, pathologically positive lymph nodes (pN+), neck metastasis level, extracapsular spread, local recurrence, neck recurrence, locoregional control, and postoperative radiotherapy were related to the occurrence of DM. According to multiple logistic analyses, pN+, involvement of neck levels 4 and 5, and local recurrence were independent risk factors for DM.Conclusions. pN+, metastasis to the lower neck, and local recurrence were risk factors for DM in patients with oral cancer.