Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression
Increased detection of serum HHV-6 DNA sequences during multiple sclerosis (MS) exacerbations and correlation with parameters of MS disease progression
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DOI：
10.1080/13550280290049615-1
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发表时间：
2002-06-01
影响因子：
3.2
通讯作者：
Jacobson, S
中科院分区：
文献类型：
--
作者：
Berti, R;Brennan, MB;Jacobson, S
近年来，人类疱疹病毒6型(HHV-6)被认为可能是MS的致病因素，为了确定MS患者血清中HHV-6DNA的检测是否与MS疾病进展的临床参数相关，对59例MS患者进行了前瞻性的5个月随访，共采集215份血清标本。用套式聚合酶链式反应分析这些样本中HHV-6DNA的存在，并与MS疾病活动性进行平行比较。HHV-6DNA扩增在临床急性加重期的样本中占22%(4/18)。临床缓解期MS患者血清HHV-6DNA阳性者显著减少(P=0.008)，为5.6%(11/197)。这项工作表明，血清HHV-6DNA的检测与MS的临床恶化显著相关。此外，本研究的结果证实了先前支持MS与HHV-6相关的报道，并提示这种人类疱疹病毒在MS的发病机制中发挥了作用。
In recent years, human herpesvirus 6 (HHV-6) has been investigated as a possible causative agent for MS. To determine if the detection of HHV-6 DNA in the serum of MS patients correlates with clinical parameters of MS disease progression, a total of 215 serum samples was obtained from 59 MS patients followed prospectively for a 5-month period. These samples were analyzed for the presence of HHV-6 DNA by nested PCR and compared in parallel to MS disease activity. HHV-6 DNA was amplified in 22% (4/18) of samples obtained during a period of clinical exacerbation. Significantly fewer (P = 0.008) sera, 5.6% (11/197), obtained from MS patients during clinical remission tested positive for the presence of HHV-6 DNA. This work demonstrates that the detection of serum HHV-6 DNA is significantly correlated with clinical exacerbations in MS. Moreover, the findings presented in this study have confirmed previous reports supporting an association between MS and HHV-6 and suggest a role for this human herpesvirus in the pathogenesis of MS.