Meeting report: 3rd workshop of the peptide ADME discussion group
Meeting report: 3rd workshop of the peptide ADME discussion group
复制标题
会议报告：肽ADME讨论组第三次研讨会
DOI：
10.1080/00498254.2021.2020377
复制
发表时间：
2021
期刊：
影响因子：
1.8
通讯作者：
J. Christensen
中科院分区：
文献类型：
--
作者：
A. Sonesson;I. Bjørnsdottir;J. Christensen
摘要在2021年2月3日举行的第三届多肽ADME讨论小组在线研讨会上，对多肽ADME面临的挑战和机遇(吸收、分布、代谢和消除)进行了介绍和讨论。这篇文章总结了这次研讨会的演讲和讨论。内容涉及：多肽、药物与药物的相互作用败血症休克对多肽PK和Pd的影响代谢产物鉴定MS处理软件多肽在临床前药物开发中的应用多肽的体外免疫原性检测策略吸入性多肽的稳定性检测和自动LC-MS联用
Abstract Challenges and opportunities within peptide ADME (absorption, distribution, metabolism and elimination) were presented and discussed at the 3rd online workshop of the Peptide ADME Discussion Group (3rd of February 2021). This article summarises the presentations and discussions from this workshop. The following topics were covered: Peptide drug-drug interactions Impact of septic shock on PK and PD of the peptide selepressin MS processing software for metabolite identification of peptides Profiling of peptides in preclinical drug development Strategy for immunogenicity testing of peptides In vitro stability testing of peptides for inhalation and automated LC-MS