ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE DROSOPHILA EMBRYO - GENETIC-STUDIES ON THE ROLE OF THE TOLL GENE-PRODUCT
ESTABLISHMENT OF DORSAL-VENTRAL POLARITY IN THE DROSOPHILA EMBRYO - GENETIC-STUDIES ON THE ROLE OF THE TOLL GENE-PRODUCT
复制标题
DOI：
10.1016/0092-8674(85)90274-0
复制
发表时间：
1985-01-01
期刊：
影响因子：
64.5
通讯作者：
NUSSLEINVOLHARD, C
中科院分区：
文献类型：
--
作者：
ANDERSON, KV;JURGENS, G;NUSSLEINVOLHARD, C
在果蝇胚胎的背腹模式的建立所必需的母体效应基因组中，Toll基因发生突变，从而产生各种各样的胚胎表型。功能等位基因的缺失产生隐性母性效应的背生胚。功能等位基因的显性获得导致腹型胚。其他隐性等位基因引起部分背侧化或偏侧化的胚胎模式。基因剂量研究表明，显性腹型的结果从Toll产品的活性改变。互补研究显示了Toll产物拷贝之间的特定反式相互作用。双突变表型表明，其他几个背组基因的产物调节Toll的活性。
Within the group of maternal effect genes necessary for the establishment of the dorsal-ventral pattern of the Drosophila embryo, the Toll gene mutates to give a singular variety of embryonic phenotypes. Lack of function alleles produce dorsalized embryos as a recessive maternal effect. Dominant gain of function alleles result in ventralized embryos. Other recessive alleles cause partial dorsalization or lateralization of the embryonic pattern. Gene dosage studies indicate that the dominant ventralized phenotype results from an altered activity of the Toll product. Complementation studies show specific trans interactions between copies of the Toll product. Double mutant phenotypes suggest that the products of several other dorsal-group genes regulate the activity of Toll.