Regulation of the nascent brain vascular network by neural progenitors.
Regulation of the nascent brain vascular network by neural progenitors.
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DOI：
10.1016/j.mod.2015.06.005
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发表时间：
2015-11
影响因子：
2.6
通讯作者：
Huang Z
中科院分区：
文献类型：
--
作者：
Santhosh D;Huang Z
神经祖细胞是大脑神经回路发育的核心参与者。它们不仅在大脑中产生不同的神经元和神经胶质细胞类型，而且在这个过程中引导它们的迁移。最近的证据表明，神经祖细胞在脑血管网络的发育中也起着关键作用。在早期阶段，已经发现神经祖细胞通过VEGF和经典Wnt信号传导促进血管从神经管外部进入。随后，神经祖细胞直接与内皮细胞通讯以稳定新生脑血管，部分通过下调Wnt通路活性。此外，神经祖细胞通过整合素αvβ8依赖性TGFβ信号传导促进新生脑血管的完整性。在这篇综述中，我们将讨论的证据，以及仍然存在的问题，关于这些新的作用的神经祖细胞和其调节新生的脑血管网络的潜在机制。
Neural progenitors are central players in the development of the brain neural circuitry. They not only produce the diverse neuronal and glial cell types in the brain, but also guide their migration in this process. Recent evidence indicates that neural progenitors also play a critical role in the development of the brain vascular network. At an early stage, neural progenitors have been found to facilitate the ingression of blood vessels from outside the neural tube, through VEGF and canonical Wnt signaling. Subsequently, neural progenitors directly communicate to endothelial cells to stabilize nascent brain vessels, in part through down-regulating Wnt pathway activity. Furthermore, neural progenitors promote nascent brain vessel integrity, through integrin αvβ8-dependent TGFβ signaling. In this review, we will discuss the evidence for, as well as questions that remain, regarding these novel roles of neural progenitors and the underlying mechanisms in their regulation of the nascent brain vascular network.