TUMOR REJECTION AFTER DIRECT COSTIMULATION OF CD8+ T-CELLS BY B7-TRANSFECTED MELANOMA-CELLS
TUMOR REJECTION AFTER DIRECT COSTIMULATION OF CD8+ T-CELLS BY B7-TRANSFECTED MELANOMA-CELLS
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DOI：
10.1126/science.7678351
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发表时间：
1993-01-15
期刊：
影响因子：
56.9
通讯作者：
ALLISON, JP
中科院分区：
文献类型：
--
作者：
TOWNSEND, SE;ALLISON, JP
多种肿瘤具有潜在的免疫原性，但在体内不能激发有效的抗肿瘤免疫反应。肿瘤可能能够向T细胞传递抗原特异性信号，但可能无法传递T细胞完全激活所必需的共刺激信号。共刺激配体B7在黑色素瘤细胞上的表达可诱导小鼠黑色素瘤的体内排斥反应。这种排斥反应由CD8+ T细胞介导；不需要CD4+ T细胞。这些结果表明，B7的表达使肿瘤细胞能够有效地呈递抗原，从而在体内消灭它们。
A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7 on melanoma cells was found to induce the rejection of a murine melanoma in vivo. This rejection was mediated by CD8+ T cells; CD4+ T cells were not required. These results suggest that B7 expression renders tumor cells capable of effective antigen presentation, leading to their eradication in vivo.