Cell biology of arterial proteoglycans.
Cell biology of arterial proteoglycans.
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DOI：
10.1161/01.atv.9.1.1
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Thomas N. Wight
中科院分区：
文献类型：
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作者：
Thomas N. Wight
虽然蛋白聚糖是血管组织的一个次要组成部分，但这些分子已被证明可以影响许多动脉特性，如粘弹性、渗透性、脂质代谢、止血和血栓形成。早期和晚期动脉粥样硬化的一个标志是内膜病变中蛋白多糖的积累。然而，目前尚不清楚为什么会出现这种积累。本文综述了由动脉壁两种主要细胞类型——内皮细胞和平滑肌细胞合成的蛋白聚糖的种类。然后详细考虑蛋白聚糖代谢的调节以及蛋白聚糖在许多细胞事件中所起的作用，如粘附、迁移和增殖——血管发育和发病机制中的重要过程。最后，回顾了蛋白聚糖在两个关键血管壁过程中的作用——止血和脂质代谢，因为这些事件与动脉粥样硬化有关。这篇综述强调了蛋白聚糖在调节血管组织正常和病理生理过程中的几个关键事件中的重要性。
Although proteoglycans constitute a minor component of vascular tissue, these molecules have been shown to influence a number of arterial properties such as viscoelasticity, permeability, lipid metabolism, hemostasis, and thrombosis. A hallmark of early and late atherosclerosis is the accumulation of proteoglycans in the intimal lesions. Yet, it is not clear why this accumulation occurs. This article reviews the classes of proteoglycans synthesized by the two major cell types of the arterial wall--the endothelial and smooth muscle cell. Detailed consideration is then given to the modulation of proteoglycan metabolism and the role that proteoglycans play in a number of cellular events such as adhesion, migration, and proliferation--important processes in both the development and the pathogenesis of blood vessels. Last, the involvement of proteoglycans in two critical vascular wall processes--hemostasis and lipid metabolism--is reviewed, because these events pertain to atherogenesis. This review emphasizes the importance of proteoglycans in regulating several key events in normal and pathophysiological processes in the vascular tissue.