The presence of arachnoiditis affects the characteristics of CSF flow in the spinal subarachnoid space: A modelling study
The presence of arachnoiditis affects the characteristics of CSF flow in the spinal subarachnoid space: A modelling study
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DOI：
10.1016/j.jbiomech.2012.01.050
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发表时间：
2012-04-30
影响因子：
2.4
通讯作者：
Bilston, Lynne E.
中科院分区：
文献类型：
--
作者：
Cheng, Shaokoon;Stoodley, Marcus A.;Bilston, Lynne E.
脊髓空洞症是一种神经系统疾病，以脊髓内充满液体的高压囊肿为特征。脊髓空洞症与中枢神经系统异常导致脑脊液流动受阻有关，因此认为脑脊液动力学的改变在其发病机制中起重要作用。利用脊髓蛛网膜下腔（SAS）的三维计算模型，本研究旨在确定SAS阻塞，如蛛网膜炎，CSF动力学在SAS中的变化。根据一系列MRI图像重建SAS的几何形状。脑脊液是一种不可压缩的牛顿流体，其动态黏度为1mpa s。三种计算模型分别模拟了脑脊液在无阻塞的SAS中的流动，以及在SAS被模拟蛛网膜炎的多孔区域阻塞的情况下的流动。背侧蛛网膜炎模型的渗透性不同。结果表明蛛网膜炎增加了SAS的血流阻力，这伴随着蛛网膜炎区域脑脊液压降的幅度和/或时间（相对于心脏周期）的适度增加和改变。本研究提示，鼻窦的形成可能与颞叶脑脊液脉冲压力动力学的变化有关。(C) 2012 Elsevier Ltd.版权所有。
Syringomyelia is a neurological disorder characterised by high pressure fluid-filled cysts within the spinal cord. As syringomyelia is associated with abnormalities of the central nervous system that obstruct cerebrospinal fluid (CSF) flow, it is thought that changes in CSF dynamics play an important role in its pathogenesis. Using three-dimensional computational models of the spinal subarachnoid space (SAS), this study aims to determine SAS obstructions, such as arachnoiditis, change in CSF dynamics in the SAS. The geometry of the SAS was reconstructed from a series of MRI images. CSF is modelled as an incompressible Newtonian fluid with a dynamic viscosity of 1 mPa s. Three computational models simulated CSF flow in either the unobstructed SAS, or with the SAS obstructed by a porous region simulating dorsal or circumferential arachnoiditis. The permeability of this porous obstruction was varied for the model with dorsal arachnoiditis. The results show that arachnoiditis increases flow resistance in the SAS and this is accompanied by a modest increase in magnitude and/or shift in timing (with respect to the cardiac cycle) of the CSF pressure drop across the region of arachnoiditis. This study suggests that syrinx formation may be related to a change in temporal CSF pulse pressure dynamics. (C) 2012 Elsevier Ltd. All rights reserved.