Malignant meningitis: A rational approach to cerebrospinal fluid cytology
Malignant meningitis: A rational approach to cerebrospinal fluid cytology
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DOI：
10.1136/jcp.49.6.497
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发表时间：
1996-06-01
影响因子：
3.4
通讯作者：
MacKenzie, JM
中科院分区：
文献类型：
--
作者：
MacKenzie, JM
目的 - 阐明脑脊液 (CSF) 细胞学实验室指南。方法 - 回顾了 54 名脑脊液中细胞学恶性细胞患者的临床和病理数据，以及 29 名患者的脑脊液细胞计数和蛋白质测量结果。利用这些数据，建立了脑脊液细胞学检查标准，并通过对 100 名未根据这些标准进行脑脊液细胞学检查的患者进行审查进行验证。结果-只有 1 例基于 CSP 的恶性肿瘤假阳性诊断；细胞学。所有脑脊液中含有恶性细胞的患者至少满足以下标准之一：临床已知或疑似恶性肿瘤；细胞计数增加；蛋白质浓度升高。在未进行细胞学检查的 100 名患者中，无一例漏掉了恶性脑膜炎的诊断。 结论——应对所有已知或疑似恶性肿瘤患者的脑脊液标本进行细胞学检查，但在其他情况下，只有当细胞计数或蛋白质浓度或两者均升高时才进行细胞学检查。
Aim-To clarify laboratory guidelines for cerebrospinal fluid (CSF) cytology.Methods-Clinical and pathological data relating to 54 patients with cytologically malignant cells in the CSF were reviewed, together with CSF cell counts and protein measurements for 29 patients. Utilising this data, criteria were established for CSF cytology and validated by review of 100 patients in whom CSF cytology had not been carried out on the basis of these criteria.Results-There was only one false positive diagnosis of malignancy on the basis of CSP; cytology. All patients with malignant cells in the CSF fulfilled at least one of the following criteria: clinically known or suspected malignancy; raised cell count; raised protein concentration. In none of the 100 patients, in whom cytology was not performed, was the diagnosis of malignant meningitis missed.Conclusion-Cytology should be performed on CSF specimens from all patients with known, or suspected, malignancy, but in other cases, only if the cell count or protein concentration, or both, is raised.