Intraoperative chemonucleolysis as an adjunct to lumbar discectomy.
Intraoperative chemonucleolysis as an adjunct to lumbar discectomy.
复制标题
术中化学溶核术作为腰椎间盘切除术的辅助手段。
DOI：
10.1097/00007632-199509000-00015
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发表时间：
1995
期刊：
影响因子：
3
通讯作者：
Jane,JA
中科院分区：
文献类型：
--
作者：
Sagher,O;Szabo,TA;Chenelle,AG;Jane,JA
研究设计：这是一篇关于1985年至1989年间在弗吉尼亚大学接受腰椎间盘切除术和化学核溶解术的104例患者的报告。目的：主要目的是确定该手术的安全性。第二个目标是开始研究它的功效。背景资料摘要：这是关于开放手术中使用乳清蛋白的第一篇报道。方法：选择经保守治疗仍未治愈的腰痛伴神经根性症状患者，术中向椎间盘间隙注射乳清蛋白酶2 ml。患者平均随访5年。对患者进行疼痛缓解调查，并对手术失败进行分析。结果：70%的患者报告良好或极好的疼痛缓解。以同一水平再次手术为特征的手术失败率为9.6%。再次手术时椎间盘突出复发率为4.8%。结论：手术是安全的，疼痛的缓解与其他已发表的系列相似。建议椎间盘突出的复发率降低。
Study Design: This is a report of a series of 104 patients who underwent lumbar discectomy and chemonucleolysis at the University of Virginia between 1985 and 1989.Objective: The primary objective was to determine the safety of this procedure. A secondary objective was to begin studying its efficacy.Summary of Background Data: This is the first report on the use of chymopapain during open surgery.Methods: Patients with low back pain and radicular symptoms not cured with conservative therapy were selected for participation in the study, Intraoperetively, disc spaces were injected with 2 ml of chymopapain. Patients were followed-up for an average of 5 years. Patients were surveyed regarding pain relief, and failures of the procedure were analyzed.Results: Seventy percent of patients reported good or excellent pain relief. Operative failures, characterized by reoperation at the same level, totaled 9.6%. Recurrent disc herniation at the time of reoperation occurred in 4.8%.Conclusion: The procedure is safe and the relief of pain was similar to that in other published series. The suggestion is that the rate of recurrent disc herniation is reduced.