Reproducibility of fMRI results across four institutions using a spatial working memory task
Reproducibility of fMRI results across four institutions using a spatial working memory task
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DOI：
10.1006/nimg.1998.0360
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发表时间：
1998-10-01
期刊：
影响因子：
5.7
通讯作者：
Turski, P
中科院分区：
文献类型：
--
作者：
Casey, BJ;Cohen, JD;Turski, P
四个美国站点组成了一个联盟，对功能磁共振方法进行多站点研究。该联盟的主要目的是检查功能磁共振结果的可靠性和重复性。FMRI数据是在四个不同机构执行空间工作记忆任务期间收集的健康成年人的数据。提供了来自每个机构的两组数据。首先，来自两个受试者的数据从每个站点都可以获得，并作为一个汇集的数据集进行处理和分析。其次，提供了每个站点5至8个受试者的统计地图。这些图像在立体定向空间中排列，并检查常见的激活区，以解决当图像采集和分析随着位置的不同而变化时，fMRI结果的重复性。我们的分组和个人数据分析显示，在所有四个地点的工作记忆任务执行期间，背外侧前额叶皮质和后顶叶皮质都有可靠的激活模式。这项多站点研究是第一次使用功能磁共振数据进行此类研究，证明了跨站点的高度一致的发现。(C)1998年学术出版社。
Four U.S. sites formed a consortium to conduct a multisite study of fMRI methods. The primary purpose of this consortium was to examine the reliability and reproducibility of fMRI results. FMRI data were collected on healthy adults during performance of a spatial working memory task at four different institutions. Two sets of data from each institution were made available. First, data from two subjects were made available from each site and were processed and analyzed as a pooled data set. Second, statistical maps from five to eight subjects per site were made available. These images were aligned in stereotactic space and common regions of activation were examined to address the reproducibility of fMRI results when both image acquisition and analysis vary as a function of site. Our grouped and individual data analyses showed reliable patterns of activation in dorsolateral prefrontal cortex and posterior parietal cortex during performance of the working memory task across all four sites. This multisite study, the first of its kind using fMRI data, demonstrates highly consistent findings across sites. (C) 1998 Academic Press.