Comparison of the Accumulation Kinetics of L-(Methyl-11C)-Methionine and D-(Methyl-11C)-Methionine in Brain Tumors Studied with Positron Emission Tomography
Comparison of the Accumulation Kinetics of L-(Methyl-11C)-Methionine and D-(Methyl-11C)-Methionine in Brain Tumors Studied with Positron Emission Tomography
复制标题
正电子发射断层扫描研究脑肿瘤中 L-(甲基-11C)-蛋氨酸和 D-(甲基-11C)-蛋氨酸积累动力学的比较
作者：
M. Bergström;H. Lundqvist;K. Ericson;A. Lilja;P. Johnström;B. Långström;H. Holst;L. Eriksson;G. Blomqvist
五名神经胶质瘤患者在服用 11C-L-蛋氨酸后以及第二天服用 11C-D-蛋氨酸后接受了正电子发射断层扫描检查。根据Patlak等人的图形技术测定肿瘤和正常脑组织中示踪剂的积累速率。 (24)。肿瘤中L-蛋氨酸的积累率平均比D-蛋氨酸高2.4倍。正常脑组织的相应比率为2.3。结论是，在这组没有明显血液肿瘤屏障破坏的肿瘤中，与正常脑组织具有相似特性的立体特异性过程导致了标记的蛋氨酸的积累。
Five patients with glioma were examined with positron emission tomography after the administration of 11C-L-methionine and at a following day with 11C-D-methionine. The rates of accumulation of the tracers were determined in the tumor and in the normal brain tissue according to a graphical technique of Patlak et coll. (24). The accumulation rates for L-methionine were on the average 2.4 times higher than those of D-methionine in the tumors. The corresponding ratio for normal brain tissue was 2.3. It is concluded that in this group of tumors without obvious blood-tumor-barrier breakdown, a stereospecific process with similar properties as in the normal brain tissue, is responsible for the accumulation of the labelled methionine.