Community-acquired Klebsiella pneumoniae central nervous system infections in adults in Singapore
Community-acquired Klebsiella pneumoniae central nervous system infections in adults in Singapore
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DOI：
10.1007/s10096-003-0963-x
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发表时间：
2003-08-01
影响因子：
4.5
通讯作者：
Tambyah, PA
中科院分区：
文献类型：
--
作者：
Habib, AG;Tambyah, PA
据报道，在两年的时间里，新加坡六名非神经外科成年患者发生了一系列成功控制的中枢神经系统（CNS）社区获得性肺炎克雷伯菌感染。三名患者出现脓肿并已引流，三名患者患有脑膜炎；所有患者均接受第三代头孢菌素治疗。所有六名患者均为中年人，其中三人是食品处理人员。临床医生应意识到肺炎克雷伯菌是一种重要的中枢神经系统病原体，特别是在东亚。尽管第三代头孢菌素对肺炎克雷伯菌中枢神经系统感染的结果产生了重大影响，但产生超广谱β-内酰胺酶菌株的出现可能导致其在这种临床环境中的疗效降低。
A series of successfully managed community-acquired Klebsiella pneumoniae infections of the central nervous system (CNS) that occurred in six non-neurosurgical adult patients in Singapore over a 2-year period is reported. Three patients had abscesses that were drained, and three had meningitis; all were treated with third-generation cephalosporins. All six patients were middle-aged adults, three of whom were food handlers. Clinicians should be aware of Klebsiella pneumoniae as an important CNS pathogen, particularly in East Asia. Although third-generation cephalosporins have had a major impact on the outcome of Klebsiella pneumoniae CNS infections, the emergence of extended-spectrum beta-lactamase-producing strains may lead to their reduced efficacy in this clinical setting.