GP73 expression and its significance in the diagnosis of hepatocellular carcinoma: a review.
GP73 expression and its significance in the diagnosis of hepatocellular carcinoma: a review.
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发表时间：
2012
影响因子：
1.4
通讯作者：
Mingchen Ba;H. Long;Yun-Qiang Tang;S. Cui
中科院分区：
文献类型：
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作者：
Mingchen Ba;H. Long;Yun-Qiang Tang;S. Cui
肝细胞癌（Hepatocellular carcinoma，HCC）是最常见的恶性肿瘤之一，其发病率在世界范围内呈上升趋势。血清甲胎蛋白（AFP）水平和腹部超声已被广泛用于HCC的诊断和监测。然而，AFP水平和超声监测HCC的敏感性和特异性都有一些缺点，特别是在疾病的早期阶段。高尔基体蛋白-73（GP 73）是一种II型高尔基体定位的整合膜蛋白，通常在许多人体组织的上皮细胞中表达。它对人类生存至关重要，并且可能在上皮细胞功能（如肾脏和肝脏）中发挥多种作用。然而，其生化功能和GP 73表达调控的细节目前尚不清楚。GP 73表达在来自肝病患者的血清样品中上调，其中在HCC中表达最高。因此，它可能是一个新的血清标志物检测肝癌的高危人群。但是，这一假设需要在大量的队列中得到证明。
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and its incidence has been increasing worldwide. Serum alpha-fetoprotein (AFP) levels and abdominal ultrasound have been widely used for diagnosis as well as surveillance of HCC. However, the sensitivity and specificity of both AFP levels and ultrasound for HCC surveillance have some shortcomings, particularly in the early stages of the disease. Golgi protein-73 (GP73) is a type II Golgi-localized integral membrane protein that is normally expressed in epithelial cells of many human tissues. It is essential for human survival, and might have multiple roles for GP73 in epithelial cell function such as in the kidney and liver. However, details of its biochemical function and regulation of GP73 expression are unknown at present. GP73 expression is upregulated in serum samples from patients with liver disease, with expression being highest in HCC. Therefore, it may be useful as a new serum marker for detection of HCC in at high-risk population. But, this hypothesis needs to be proven in large cohorts.