Tuning the Permeability of Polymer Hydrogel Capsules: An Investigation of Cross-Linking Density, Membrane Thickness, and Cross-Linkers
Tuning the Permeability of Polymer Hydrogel Capsules: An Investigation of Cross-Linking Density, Membrane Thickness, and Cross-Linkers
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DOI：
10.1021/la104510e
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发表时间：
2011-03-01
期刊：
影响因子：
3.9
通讯作者：
Caruso, Frank
中科院分区：
文献类型：
--
作者：
Chong, Siow-Feng;Lee, Ji Hyun;Caruso, Frank
纳米工程聚（甲基丙烯酸）水凝胶胶囊（PMA HC）是有前途的候选载体的生物医学应用，特别是在药物输送，封装催化，和细胞模拟领域。这些载体的组装、稳定性和降解以及它们用于包封治疗剂的用途已经受到相当大的关注。然而，调整PMA HC的渗透性性质以适应各种类型的货物仍然在很大程度上未被探索。在这里，我们调查的基本参数，支配的结构完整性和能力的PM A HC封装大分子货物。组成聚合物的硫醇含量和沉积的聚合物层的数量被证明是控制PMA HC内的货物保留的关键因素。我们进一步引入了一种新的策略，通过硫醇二硫键交换实现PMA HC的二硫键交联，以获得具有上级货物保留特性的胶囊。最后，我们提供的证据PMA HC的半渗透性的基础上的电荷的溶质，并表明，这些系统的合理设计可以产生特定的货物保留性能的胶囊。这项工作有助于多层聚合物胶囊和PMA HC的开发以及生物医学中的相关应用。
Nanoengineered poly(methacrylic acid) hydrogel capsules (PMA HCs) are promising candidate carriers for biomedical applications, especially in the areas of drug delivery, encapsulated catalysis, and cell mimicry. The assembly, stability, and degradation Of these carriers, as well as their use for the encapsulation of therapeutics, have received considerable attention. However, tailoring the permeability properties of PMA HCs to various types of cargo remains largely unexplored. Herein, we investigate fundamental parameters that govern the structural integrity and the capability of PM A HCs to encapsulate macromolecular cargo. The thiol content of the constituent polymers and the number of deposited polymer layers are shown to be key factors in controlling cargo retention within the PMA HCs. We further introduce a new strategy to achieve disulfide cross-linking for PMA HCs via a thiol disulfide exchange in order to obtain capsules with superior cargo retention characteristics. Finally, we provide evidence for the semipermeable nature of PMA HCs based on the charge of the solutes and demonstrate that rational design of these systems can yield capsules with specific cargo retention properties. This work contributes toward the development of multilayered polymer capsules and PMA HCs and associated applications in biomedicine.