PROBLEMS CONCERNING THE USEFULNESS OF ADJUSTMENT OF URINARY CADMIUM FOR CREATININE AND SPECIFIC-GRAVITY
PROBLEMS CONCERNING THE USEFULNESS OF ADJUSTMENT OF URINARY CADMIUM FOR CREATININE AND SPECIFIC-GRAVITY
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DOI：
10.1007/bf00378372
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发表时间：
1985-01-01
影响因子：
3
通讯作者：
GHEZZI, I
中科院分区：
文献类型：
--
作者：
BERLIN, A;ALESSIO, L;GHEZZI, I
先前的一项研究得出结论，肌酐作为调整尿液点样测定的生物指标值的参数的有效性存在疑问，因为它存在显著的个体间和个体内差异。由于肌酐水平和比密度之间仅存在中度相关性，因此可以假设这2个参数不能无差别地用于调整。似乎需要验证从现场样品测定的Cd值的校正是否提供任何实际优势。为此目的，105例职业接触镉进行了检查。8：00分别采集24 h尿和尿斑标本。CdU/点样与CdU/24 h之间存在剂量相关性。以微克/升表示的CdU/斑点值和根据肌酐或1024比重调整的值的相关指数相似。根据肌酐或比重调整CdU没有特别的优势。
A previous study concluded that there were doubts as to the validity of creatinine as a parameter for adjusting the values of biological indicators determined on spot samples of urine, since it was subject to marked inter- and intraindividual variations. Since there was only a moderate correlation between creatinine levels and specific density, it can be assumed that these 2 parameters cannot be used indifferently for adjustment. It seemed advisible to verify whether correction of Cd values determined from spot samples offered any practical advantages. For this purpose, 105 subjects with occupational exposure to Cd were examined. They collected their 24 h urine and spot samples separately at 8:00 h. There was a dose correlation between CdU/spot samples and CdU/24 h. The correlation index was similar for CdU/spot values expressed in microgram/liter and for values adjusted according to creatinine or 1024 specific gravity. No particular advantages were offered by adjusting CdU according to creatinine or specific gravity.