Decreased serum leptin in bulimia nervosa
Decreased serum leptin in bulimia nervosa
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DOI：
10.1210/jc.85.12.4511
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发表时间：
2000-12-01
影响因子：
5.8
通讯作者：
Metzger, ED
中科院分区：
文献类型：
--
作者：
Jimerson, DC;Mantzoros, C;Metzger, ED
饮食失调神经性贪食症与饱腹感受损、静息代谢率降低和神经内分泌调节异常有关。临床前研究表明，这种改变可能与瘦素功能受损有关。因此，本研究的目的是评估神经性贪食症中瘦素功能是否下降。将患有神经性贪食症的女性 (n = 18) 和从神经性贪食症中保持稳定恢复的女性 (n = 15) 测量的血清瘦素水平与健康女性对照 (n = 20) 的值进行比较。受试者在禁食过夜并卧床休息后，在月经周期的卵泡期进行研究。通过R1A分析基线血清样品的瘦素浓度。受试者组的年龄和体重相匹配。协方差分析，调整身体脂肪百分比，显示神经性贪食症组的血清瘦素水平异常低（P = 0.02），暴饮暴食频率与血清瘦素浓度之间呈负相关趋势（P < 0.1）。此外，缓解患者组的瘦素值异常低（P = 0.01）。这些结果与瘦素功能下降可能与神经性贪食症的饮食模式、代谢率和神经内分泌调节的改变有关的假设是一致的。
The eating disorder bulimia nervosa has been associated with impaired satiety, decreased resting metabolic rate, and abnormal neuroendocrine regulation. Preclinical studies suggest that such alterations could be associated with impaired leptin function. Thus, the goal of this study was to assess whether leptin function is decreased in bulimia nervosa. Serum leptin levels measured in women with bulimia nervosa (n = 18) and in women who had maintained stable recovery from bulimia nervosa (n = 15) were compared with values in healthy female controls (n = 20). Subjects were studied during the follicular phase of their menstrual cycle after an overnight fast and bed rest. Baseline serum samples were analyzed for leptin concentration by RlA. Subject groups were matched for age and body weight. Analysis of covariance, adjusting for percent body fat, demonstrated abnormally low serum leptin levels in the bulimia nervosa group (P = 0.02), with a trend toward an inverse correlation between frequency of binge episodes and serum leptin concentration (P < 0.1). Addition ally, the remitted patient group demonstrated abnormally low leptin values (P = 0.01). These results are consistent with the hypothesis that decreased leptin function may be associated with alterations in eating patterns, metabolic rate, and neuroendocrine regulation in bulimia nervosa.