MUC1 MUCIN EXPRESSION AS A MARKER OF PROGRESSION AND METASTASIS OF HUMAN COLORECTAL-CARCINOMA
MUC1 MUCIN EXPRESSION AS A MARKER OF PROGRESSION AND METASTASIS OF HUMAN COLORECTAL-CARCINOMA
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DOI：
10.1016/0016-5085(94)90592-4
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发表时间：
1994-02-01
期刊：
影响因子：
29.4
通讯作者：
IRIMURA, T
中科院分区：
文献类型：
--
作者：
NAKAMORI, S;OTA, DM;IRIMURA, T
背景/目的：MUC 1粘蛋白分布于多种上皮组织（除肠上皮外）中，并且经常在结直肠癌组织和细胞系中检测到。本研究旨在阐明MUC 1粘蛋白表达是否与结直肠癌的进展相关。方法：收集58例结直肠癌患者的113例组织标本，包括原发性结直肠癌、正常粘膜、肝转移、淋巴结转移和正常肝脏。结果：大肠癌组织中成熟MUC 1粘蛋白的表达水平明显高于正常大肠粘膜（P< 0.001）;此外，成熟MUC 1粘蛋白的水平在来自具有转移或转移性肿瘤的患者的原发性肿瘤中显著高于来自无转移患者的原发性肿瘤（P< 0.001）。结论：成熟MUC 1粘蛋白在大肠癌转移灶中异位表达，成熟MUC 1粘蛋白可作为晚期大肠癌的一个重要标志物。
Background/Aims:The MUC1 mucin distributes among a variety of epithelial tissues (except the intestinal epithelia) and is often detectable in colorectal carcinoma tissues and cell lines. This study aimed to elucidate whether MUC1 mucin expression correlated to the progression of colorectal carcinomas.Methods:We collected 113 tissue specimens, including primary colorectal carcinoma, normal mucosa, liver metastases, lymph node metastases, and normal livers from 58 patients with colorectal carcinoma. Immunohistochemical staining and Western blotting analysis with mature MUC1 mucin-specific monoclonal antibodies were performed.Results:The levels of mature MUC1 mucins were significantly higher in carcinoma tissues than those in normal colonic mucosa (P< 0.001). Furthermore, the levels of mature MUC1 mucins were significantly higher in primary tumors from patients having metastasis or metastatic tumors than in primary tumors from patients without metastasis (P< 0.001). In the primary sites, mature MUC1 mucin levels apparently increased according to progression of the stages (P< 0.001).Conclusions:These results strongly suggest that mature MUC1 mucins become ectopically expressed in colorectal carcinoma progressed to the metastatic stages and that mature MUC1 mucins may be a useful marker for advanced colorectal carcinoma.