ULTRASTRUCTUAL CHANGES IN AXONS CAUSED BY ACRYLAMIDE ABOVE A NERVE LIGATURE
ULTRASTRUCTUAL CHANGES IN AXONS CAUSED BY ACRYLAMIDE ABOVE A NERVE LIGATURE
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神经结扎上方丙烯酰胺引起的轴突超结构变化
DOI：
10.1111/j.1365-2990.1981.tb00103.x
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发表时间：
1981
影响因子：
5
通讯作者：
M. F. GYSBERS
中科院分区：
文献类型：
--
作者：
J. Cavanagh;M. F. GYSBERS
本文描述了丙烯酰胺在神经结扎点以上周围神经引起的上升变性的超微结构特征。在轴突变性的迹象出现之前，平滑内质网和囊泡的大量积聚尤其发生在Ranvier淋巴结的近端，但也发生在结间区域。一些线粒体聚集发生在Ranvier淋巴结远端。这些变化与正常动物神经挤压上方4毫米轴突的变化非常相似，并且本质上似乎是非特异性的。它们与随后的轴突退化的关系的重要性只能猜测。
The ultrastructural features of the ascending degeneration produced by acrylamide in peripheral nerves above the point of nerve ligature have been described. Before the onset of signs of axonal degeneration abundant accumulations of smooth endoplasmic reticulum and vesicles occur particularly proximal to nodes of Ranvier, but also in internodal regions. Some mitochondrial accumulations occur distal to nodes of Ranvier. The changes closely resemble those found in axons up to 4 mm above a nerve crush in normal animals and appear to be essentially non‐specific in nature. Their significance in relation to the subsequent axonal degeneration can only be guessed at.