Multicompartment micelles from silicone-based triphilic block copolymers
Multicompartment micelles from silicone-based triphilic block copolymers
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DOI：
10.1007/s00396-013-3001-2
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发表时间：
2013-06
影响因子：
2.4
通讯作者：
Jean-Noel Marsat;Frank Stahlhut;A. Laschewsky;H. Berlepsch;C. Böttcher
中科院分区：
文献类型：
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作者：
Jean-Noel Marsat;Frank Stahlhut;A. Laschewsky;H. Berlepsch;C. Böttcher
通过可逆加成-断裂链转移聚合，连续三步合成了一种两亲性线性三元嵌段共聚物。以低聚(乙二醇单甲醚)丙烯酸酯为亲水嵌段，丙烯酸苄酯和3-三(三甲基硅氧基)硅丙基丙烯酸酯为疏水嵌段。由此得到的“三亲”共聚物包括一个亲水的(A)和两个互不相容的“软”疏水嵌段，即一个亲脂的(B)和一个基于有机硅的(C)嵌段，所有嵌段的玻璃化转变温度都低于0℃。三亲共聚物在水溶液中自组装成球形的多嵌段胶束聚集体，其中两个疏水嵌段发生局部相分离，形成各种超微结构，低温透射电子显微镜证明。因此，在三亲嵌段共聚物中，基于有机硅的聚合物嵌段可以取代迄今通常采用的基于氟碳的疏水嵌段，以诱导多隔室。
An amphiphilic linear ternary block copolymer was synthesised in three consecutive steps via reversible addition–fragmentation chain transfer polymerisation. Oligo(ethylene glycol) monomethyl ether acrylate was engaged as a hydrophilic building block, while benzyl acrylate and 3-tris(trimethylsiloxy)silyl propyl acrylate served as hydrophobic building blocks. The resulting “triphilic” copolymer consists thus of a hydrophilic (A) and two mutually incompatible “soft” hydrophobic blocks, namely, a lipophilic (B) and a silicone-based (C) block, with all blocks having glass transition temperatures well below 0 °C. The triphilic copolymer self-assembles into spherical multicompartment micellar aggregates in aqueous solution, where the two hydrophobic blocks undergo local phase separation into various ultrastructures as evidenced by cryogenic transmission electron microscopy. Thus, a silicone-based polymer block can replace the hitherto typically employed fluorocarbon-based hydrophobic blocks in triphilic block copolymers for inducing multicompartmentalisation.