Euphane and tirucallane triterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus
Euphane and tirucallane triterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus
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DOI：
10.1021/np0205396
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发表时间：
2003-05-01
影响因子：
5.1
通讯作者：
Kitanaka, S
中科院分区：
文献类型：
--
作者：
Wang, LY;Wang, NL;Kitanaka, S
从甘遂（Euphorbia kansui）60%EtOH提取物中分离得到4个新的丁香烷型三萜化合物，分别为kansenone（1）、kansenonol（3）、11-oxo-kansenonol（4）、kansenol（5）和一个新的替鲁卡烷型三萜化合物epi-kansenone（2）。通过对它们的1D和2D NMR光谱数据的广泛分析，阐明了它们的结构。这似乎是第一次报告的天然发生的euphane/tirucallane型三萜酮在C-7。在体外用1-4处理处于囊胚期的培养的单个非洲爪蟾细胞显著地阻止了细胞的分裂（10 mg/mL的每种化合物导致>50%的分裂阻止）。
Four new euphane-type triterpenes, kansenone (1), kansenonol (3), 11-oxo-kansenonol (4), kansenol (5), and a new tirucallane-type triterpene, epi-kansenone (2), were isolated from a 60% EtOH extract of Euphorbia kansui, together with alpha-euphol. Their structures were elucidated on the basis of extensive analysis of their 1D and 2D NMR spectral data. This appears to be the first report of the natural occurrence of euphane/tirucallane-type triterpenes with a ketone at C-7. In vitro treatment of cultured individual Xenopus laevis cells at the blastular stage with 1-4 significantly arrested cleavage of the cells (10 mg/mL of each compound resulted in >50% cleavage arrest).