The use of medical hyperspectral technology to evaluate microcirculatory chaves in diabetic foot ulcers and to predict clinical outcomes
The use of medical hyperspectral technology to evaluate microcirculatory chaves in diabetic foot ulcers and to predict clinical outcomes
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DOI：
10.2337/dc06-2209
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发表时间：
2007-04-01
期刊：
影响因子：
16.2
通讯作者：
Veves, Aristidis
中科院分区：
文献类型：
--
作者：
Khaodhiar, Lalita;Dinh, Thanh;Veves, Aristidis
目的：足部溃疡是糖尿病的一种严重并发症，新的技术可以预测伤口愈合可能会非常有帮助。我们测试的能力，医疗高光谱技术（FIT），一种新的诊断扫描技术，可以量化组织氧合和脱氧血红蛋白预测糖尿病足溃疡healing.RESEARCH设计和方法-10 I型糖尿病患者21足溃疡网站，13 I型糖尿病患者无溃疡，14 nondiabetic对照组被视为4倍以上6个月的时间。在溃疡部位或附近以及远离溃疡的上肢和下肢进行氧合血红蛋白（HT-oxy）和脱氧血红蛋白（HT-deoxy）的HT测量。HT愈合指数为每个网站计算从HT-oxy和-deoxy values.Results -高光谱组织氧合测量观察到的变化，在组织直接周围的溃疡时，比较溃疡愈合和溃疡不愈合（P < 0.001）。HT指数预测愈合的敏感性、特异性、阳性预测值和阴性预测值分别为93%、86%、93%和86%。三个危险组中，足跖区（P < 0.05）和手掌区（P < 0.01）的HT-oxy含量变化显著。HT-脱氧和HT愈合指数的变化仅见于手掌（分别为P < 0.05和P < 0.01）。结论- FIT能够识别糖尿病足的微血管异常和组织氧合，并预测溃疡愈合。FIT可以帮助管理足部溃疡。
OBJECTIVE - Foot ulceration is a serious complication of diabetes, and new techniques that can predict wound healing may prove very helpful. We tested the ability of medical hyperspectral technology (FIT), a novel diagnostic scanning technique that can quantify tissue oxy- and deoxyhemoglobin to predict diabetic foot ulcer healing.RESEARCH DESIGN AND METHODS - Ten type I diabetic patients with 21 foot ulcer sites, 13 type I diabetic patients without ulcers, and 14 nondiabetic control subjects were seen up to 4 times over a 6-month period. HT measurements of oxyhemoglobin (HT-oxy) and deoxyhemoglobin (HT-deoxy) were performed at or near the ulcer area and on the upper and lower extremity distant from the ulcer. An HT healing index for each site was calculated from the HT-oxy and -deoxy values.RESULTS - Hyperspectral tissue oxygenation measurements observed changes in tissue immediately surrounding the ulcer when comparing ulcers that heal and ulcers that do not heal (P < 0.001). The sensitivity, specificity, and positive and negative predictive values of the HT index for predicting healing were 93, 86, 93, and 86%, respectively, when evaluated on images taken at the first visit. Changes in HT-oxy among the three risk groups were noted for the metatarsal area of the foot (P < 0.05) and the palm(P < 0.01). Changes in HT-deoxy and the HT healing index were noted for the palm only (P < 0.05 and P < 0.01, respectively).CONCLUSIONS - FIT has the capability to identify microvascular abnormalities and tissue oxygenation in the diabetic foot and predict ulcer healing. FIT can assist in the management of foot ulceration.