Lifetime-comorbidity of obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in northern Germany
Lifetime-comorbidity of obsessive-compulsive disorder and subclinical obsessive-compulsive disorder in northern Germany
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DOI：
10.1007/s004060170047
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发表时间：
2001-06-01
影响因子：
4.7
通讯作者：
John, U
中科院分区：
文献类型：
--
作者：
Grabe, HJ;Meyer, C;John, U
目的尽管强迫症（OCD）在世界范围内具有广泛的相关性，但在一般人群中，强迫症和亚临床强迫症的共病数据却相当缺乏。方法德国版本，DSM-IV适应复合国际诊断访谈进行了管理的4075人年龄在18-64岁，生活在德国北方地区的代表性样本。结果强迫症和亚临床强迫症的共病抑郁障碍发生率较高，而躯体形式疼痛障碍仅与强迫症相关。在女性受试者中，强迫症还与社交和特定恐惧症、酒精、尼古丁和镇静剂依赖、创伤后应激障碍和非典型进食障碍相关。结论：由于低共病率，亚临床强迫症似乎是一个独立的综合征，不限于其他轴1诊断的存在。强迫症和亚临床强迫症的共病模式显示出焦虑和抑郁障碍的倾向。在我们的一般人群样本中，无法证实与强迫性谱系障碍的广泛关联。
Objective Inspite of the worldwide relevance of obsessive-compulsive disorder (OCD), there is a substantial lack of data on comorbidity in OCD and subclinical OCD in the general population. Methods German versions, of the DSM-IV adapted Composite International Diagnostic Interview were administered to a representative sample of 4075 persons aged 18-64 years, living in a northern German region. Results In both genders, high rates of comorbid depressive disorders were found in OCD and subclinical OCD, whereas somatoform pain disorder was only associated with OCD. In female subjects,,OCD was additionally associated with social and specific phobias, alcohol, nicotine and sedative dependence, PTSD and atypical eating, disorder. Conclusion Due to low comorbidity rates, subclinical OCD seems to represent an independent syndrome not restricted to the presence of other axis-1 diagnoses. Comorbidity patterns show a disposition to, anxiety and to depressive disorders in OCD and subclinical OCD. A broad association with obsessive-compulsive spectrum disorders could not be confirmed in our general population sample.