Cytokine-containing liposomes as adjuvants for subunit vaccines.

Cytokine-containing liposomes as adjuvants for subunit vaccines.
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含有细胞因子的脂质体作为亚单位疫苗的佐剂。

DOI:
10.1007/978-1-4615-1823-5_29
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发表时间:
1995
期刊:
Pharmaceutical biotechnology.
影响因子:
--
通讯作者:
Cleland,JL
Cleland,JL
中科院分区:
--
文献类型:
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作者:
Lachman,LB;Shih,LC;Rao,XM;Ullrich,SE;Cleland,JL

文献摘要

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脂质体提供了将抗原带到免疫系统细胞的载体功能,并提供了缓慢释放抗原的机制。由于脂质体被缓慢吸收,它们还提供了“储库效应”,其中与可溶性抗原相比,抗原的存在可以维持更长的时间段(Alving,1991)。除了抗原之外,脂质体还可以携带增强免疫应答的其他试剂。在这一章中,我们将介绍我们目前的数据有关的佐剂效应的一种特殊类型的脂质体含有亚单位蛋白抗原和细胞因子。
Liposomes provide a carrier function to bring antigen to cells of the immune system and to provide a mechanism for slow release of antigen. Since liposomes are slowly absorbed, they also provide a “depot effect” in which the presence of the antigen may be maintained for a longer period of time compared to soluble antigen (Alving, 1991). In addition to antigen, liposomes may carry other agents that potentiate an immune response. In this chapter we will present our current data concerning the adjuvant effect of a special type of liposomes containing a subunit protein antigen and cytokines.