Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development
Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development
复制标题
重症发热伴血小板减少综合征疫苗研制现状
DOI：
10.1016/j.coviro.2018.03.005
复制
发表时间：
2018-04-01
影响因子：
5.9
通讯作者：
Barrett, Alan D. T.
中科院分区：
文献类型：
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作者：
Reece, Lisa M.;Beasley, David W. C.;Barrett, Alan D. T.
重症发热伴血小板减少综合征（SFTS）是由静脉病毒（SFTS病毒）引起的一种新型蜱传疾病。该病毒于2009年在中国中部被发现，此后在日本和韩国都被发现。在病毒的分子生物学方面已取得重大进展，并已用于开发诊断分析和试剂。在流行病学、维持和传播、临床表现、免疫反应和治疗方案方面取得的进展较小。已经研究了许多动物模型，但迄今为止，没有一个能概括在人类中观察到的所有临床表现。疫苗开发处于早期发现阶段。
Severe Fever with Thrombocytopenia Syndrome (SFTS) is a new emerging tick-borne disease caused by the phlebovirus, SFTS virus (SFTSV). The virus was discovered in central China in 2009 and has since been identified in both Japan and South Korea. Significant progress has been made on the molecular biology of the virus, and this has been used to develop diagnostic assays and reagents. Less progress has been made on the epidemiology, maintenance and transmission, clinical manifestations, immunological responses, and treatment regimens. A number of animal models have been investigated but, to date, none recapitulate all the clinical manifestations seen in humans. Vaccine development is at an early discovery phase.