Epigenetic age acceleration and metabolic syndrome in the coronary artery risk development in young adults study
Epigenetic age acceleration and metabolic syndrome in the coronary artery risk development in young adults study
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DOI：
10.1186/s13148-019-0767-1
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发表时间：
2019-11-15
影响因子：
5.7
通讯作者：
Hou, Lifang
中科院分区：
文献类型：
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作者：
Nannini, Drew R.;Joyce, Brian T.;Hou, Lifang
背景代谢综合征（MetS）是一组代谢紊乱，可导致多种心血管疾病。先前的研究表明，更不利的代谢风险状况与更先进的生物老化有关。然而，年龄与代谢综合征的表观遗传生物标志物之间的关联还不清楚。因此，我们调查了表观遗传年龄加速和代谢综合征的严重程度评分和事件MetS.ResultsA研究参与者与可用的全血在检查年15日和20日在年轻人的冠状动脉风险发展研究进行表观基因组分析使用Illumina MethylationEPIC珠芯片（类似于850,000网站）之间的关联。根据DNA甲基化水平计算内在和外在表观遗传年龄加速（IEAA和EEAA）。在横断面分析中，MetS严重程度评分与第15年（P=0.016）和第20年（P=0.016）的IEAA以及第20年（P=0.040）的EEAA呈正相关。IEAA在20年是显着相关的事件MetS在30年（OR=1.05 [95%CI 1.01，1.10]，P=0.028）。这些发现表明，较高的MetS严重程度评分与加速的表观遗传衰老相关，并且这种衰老可能在代谢紊乱的发展中发挥作用，可能作为未来MetS的有用生物标志物和早期检测工具。
BackgroundThe metabolic syndrome (MetS) is a collection of metabolic disturbances that can lead to various cardiovascular diseases. Previous studies have shown a more adverse metabolic risk profile is associated with more advanced biological aging. The associations between epigenetic biomarkers of age with MetS, however, are not well understood. We therefore investigated the associations between epigenetic age acceleration and MetS severity score and incident MetS.ResultsA subset of study participants with available whole blood at examination years 15 and 20 from the Coronary Artery Risk Development in Young Adults Study underwent epigenomic profiling using the Illumina MethylationEPIC Beadchip (similar to 850,000 sites). Intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA) were calculated from DNA methylation levels. The MetS severity score was positively associated with IEAA at years 15 (P=0.016) and 20 (P=0.016) and EEAA at year 20 (P=0.040) in cross-sectional analysis. IEAA at year 20 was significantly associated with incident MetS at year 30 (OR=1.05 [95% CI 1.01, 1.10], P=0.028).ConclusionsTo our knowledge, this is the first report of the longitudinal association between epigenetic age acceleration and MetS. These findings suggest that a higher MetS severity score is associated with accelerated epigenetic aging and such aging may play a role in the development of metabolic disorders, potentially serving as a useful biomarker of and early detection tool for future MetS.