Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1.
Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1.
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DOI：
10.1155/2018/5408324
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发表时间：
2018
影响因子：
4.1
通讯作者：
Zhao H
中科院分区：
文献类型：
--
作者：
Fan H;Jiang C;Zhong B;Sheng J;Chen T;Chen Q;Li J;Zhao H
苦参碱可能对结直肠癌（CRC）有保护作用，但它如何起作用尚不清楚。因此，我们探讨了苦参碱在大肠癌中的潜在机制。利用网络药理学方法预测苦参碱在大肠癌中的作用靶点和苦参碱相关蛋白、相关基因。苦参碱的作用机制与IL-6、26S蛋白酶体、TNF-α、TGF-β 1、p53、HMGB1信号通路和T辅助细胞分化等5个靶点有关。在用苦参碱（ip）治疗18周的1，2-二甲基肼二盐酸盐诱导的CRC模型大鼠中验证预测的血清靶点的表达。数据显示，苦参碱抑制CRC生长并降低先前升高的IL-6、TNF-α、p53和HMGB1表达。苦参碱可能通过抑制HMGB1信号传导对CRC具有治疗作用，这是通过下调IL-6、TNF-α和HMGB1发生的。
Matrine may be protective against colorectal cancer (CRC), but how it may work is unclear. Thus, we explored the underlying mechanisms of matrine in CRC. Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine's mechanism. Expression of predicted serum targets were verified in a 1,2-dimethylhydrazine dihydrochloride-induced CRC model rats that were treated with matrine (ip) for 18 weeks. Data show that matrine suppressed CRC growth and decreased previously elevated expression of IL-6, TNF-α, p53, and HMGB1. Matrine may have had a therapeutic effect on CRC via inhibition of HMGB1 signaling, and this occurred through downregulation of IL-6, TNF-α, and HMGB1.
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DOI：
10.5114/wo.2016.65605
发表时间：
2016
期刊：
Contemporary oncology (Poznan, Poland)
影响因子：
--
作者：
Stanilov NS;Miteva L;Cirovski G;Stanilova SA
通讯作者：
Stanilova SA
HMGB1：内源性危险信号。
影响因子：
5.7
作者：
Klune, John R.;Dhupar, Rajeev;Cardinal, Jon;Billiar, Timothy R.;Tsung, Allan
通讯作者：
Tsung, Allan
影响因子：
20.1
作者：
Chan SY;Loscalzo J
通讯作者：
Loscalzo J
影响因子：
168.9
作者：
Cunningham, David;Atkin, Wendy;Starling, Naureen
通讯作者：
Starling, Naureen
影响因子：
64.8
作者：
Liu, Yunhua;Zhang, Xinna;Lu, Xiongbin
通讯作者：
Lu, Xiongbin