Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors
Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors
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DOI：
10.1002/adma.201602173
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发表时间：
2016-11-16
影响因子：
29.4
通讯作者：
Li, Yaping
中科院分区：
文献类型：
--
作者：
Sun, Huiping;Su, Jinghan;Li, Yaping
由4T1乳腺癌细胞膜和负载紫杉醇的聚合物纳米颗粒（PPN）（细胞膜涂层PPN）组成的独特仿生药物递送系统，表现出与其来源肿瘤细胞的优异相互作用和延长的血液循环，并且对同型原发肿瘤和转移瘤表现出高度细胞特异性靶向，成功抑制乳腺癌细胞的生长和肺转移。
A unique biomimetic drug-delivery system composed of 4T1-breast-cancercell membranes and paclitaxel-loaded polymeric nanoparticles (PPNs) (cell-membrane-coated PPNs), demonstrates superior interactions to its source tumor cells and elongated blood circulation, and displays highly cell-specific targeting of the homotypic primary tumor and metastases, with successful inhibition of the growth and lung metastasis of the breast cancer cells.