Epithelioid angiomyolipoma of the kidney
Epithelioid angiomyolipoma of the kidney
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DOI：
10.1111/j.1442-2042.2005.01003.x
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发表时间：
2005-02-01
影响因子：
2.6
通讯作者：
Dönmez, T
中科院分区：
文献类型：
--
作者：
Acikalin, MF;Tel, N;Dönmez, T
上皮样血管平滑肌脂肪瘤是最近发现的一种血管平滑肌脂肪瘤的变体，其特征是存在具有密集嗜酸性细胞质的多边形细胞和不同程度的核异型性。只有相对少数的病例上皮样血管平滑肌脂肪瘤的肾脏已被报道在文献中。我们报告一例上皮样血管平滑肌脂肪瘤的肾脏，发生在一个38岁的妇女。肿瘤由弥漫性上皮样细胞、脂肪细胞和分散的厚壁血管组成。上皮样细胞细胞核呈多形性、深染性，胞浆致密嗜酸性。可见出血、坏死灶及泡沫状巨噬细胞群。上皮样细胞中检测到HMB-45、CD117 （c-kit）和CD68。细胞角蛋白、上皮膜抗原、desmin均未表达。患者在肾切除术后9个月无复发或转移的迹象。
Epithelioid angiomyolipoma is a recently recognized variant of angiomyolipoma, which is characterized by the presence of polygonal cells with densely eosinophilic cytoplasm and varying degrees of nuclear atypia. Only a relatively small number of cases of epithelioid angiomyolipoma of the kidney have been reported in the literature. We report a case of epithelioid angiomyolipoma of the kidney that occurred in a 38-year-old woman. The tumor was composed of diffuse sheets of epithelioid cells, adipocytes and only scattered thick-walled blood vessels. The epithelioid cells had pleomorphic and hyperchromatic nuclei with densely eosinophilic cytoplasm. Hemorrhage, necrotic foci and clusters of foamy macrophages were present. HMB-45, CD117 (c-kit) and CD68 were detected in the epithelioid cells. There was no expression of cytokeratin, epithelial membrane antigen or desmin. The patient showed no evidence of recurrence or metastatic disease 9 months after nephrectomy.