Effects of non-occupational environmental exposure to pyrethroids on semen quality and sperm DNA integrity in Chinese men
Effects of non-occupational environmental exposure to pyrethroids on semen quality and sperm DNA integrity in Chinese men
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非职业环境接触拟除虫菊酯对中国男性精液质量和精子DNA完整性的影响
DOI：
10.1016/j.reprotox.2010.10.005
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发表时间：
2011-02-01
影响因子：
3.3
通讯作者：
Wang, Xinru
中科院分区：
文献类型：
--
作者：
Ji, Guixiang;Xia, Yankai;Wang, Xinru
在几个西方和亚洲国家的观察结果表明，精液质量下降可能与环境暴露有关。为了研究环境暴露于拟除虫菊酯对精子DNA完整性和精液质量的影响，在严格的资格筛选后，从不孕症诊所招募了240名男性。对尿3-苯氧基苯甲酸（3-PBA）浓度、精液质量和精子DNA完整性进行评价。校正潜在混杂因素后，尿3-PBA水平与精子浓度呈显著负相关（β =-0.27，95%CI：-0.41至-0.12，P < 0.001）。尿3-PBA水平与精子DNA片段化程度呈正相关（β =0.27，95%CI：0.15-0.39，P < 0.001）。我们的研究结果表明，非职业性环境拟除虫菊酯暴露可能对中国男性精子DNA完整性和精液质量产生负面影响。皇冠版权所有（c）2010由爱思唯尔公司出版。All rights reserved.
Observations in several western and Asiatic countries point toward a decline in semen quality which may be associated with environmental exposures. To investigate the effect of environmental exposure to pyrethroids on sperm DNA integrity and semen quality, 240 men were recruited from an infertility clinic through the clinic following strict eligibility screening. Urinary 3-phenoxybenzoic acid (3-PBA) concentration, semen quality, and sperm DNA integrity were evaluated. After adjustment for potential confounders, a significant inverse correlation was observed between the urinary 3-PBA level and the sperm concentration (beta= -0.27, 95%CI: -0.41 to -0.12, P < 0.001). Moreover, we also found a significant positive correlation between urinary 3-PBA level and sperm DNA fragmentation (beta=0.27, 95%CI: 0.15-0.39, P < 0.001). Our results suggest that non-occupational environmental pyrethroids exposure may have a negative impact on sperm DNA integrity and semen quality in Chinese males. Crown Copyright (c) 2010 Published by Elsevier Inc. All rights reserved.