One-step synthesis of a fluorescein derivative and mechanistic studies
One-step synthesis of a fluorescein derivative and mechanistic studies
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DOI：
10.1016/j.tetlet.2012.07.084
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发表时间：
2012-09-26
影响因子：
1.8
通讯作者：
Koide, Kazunori
中科院分区：
文献类型：
--
作者：
Cook, Michael P.;Ando, Shin;Koide, Kazunori
报道了一种在酸性条件下一步合成荧光素衍生物的简便方法。机理研究表明，酸促进的缩合邻甲苯甲醛和4-氯间苯二酚形成的荧光素衍生物的收益通过环化-氧化途径，而另一种氧化-环化途径仍然是可能的。(c)2012爱思唯尔有限公司保留所有权利。
We report a convenient method for the one-step synthesis of a fluorescein derivative under acidic conditions. Mechanistic studies indicate that the acid-promoted condensation of o-tolualdehyde and 4-chlororesorcinol to form the fluorescein derivative proceeds through a cyclization-oxidation pathway while an alternative oxidation-cyclization pathway remains possible. (c) 2012 Elsevier Ltd. All rights reserved.